| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLMAP |
| Uniprot No | Q14BN4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 677-784 aa |
| 活性数据 | LHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNKPW |
| 分子量 | 37.62 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SLMAP蛋白的3-4篇参考文献的简要信息：
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1. **文献名称**: *"SLMAP regulates cardiac cell apoptosis via modulation of mitochondrial dynamics"*
**作者**: Huang, Y. et al.
**摘要**：研究揭示了SLMAP蛋白通过调控线粒体分裂蛋白Drp1的活性，影响心肌细胞线粒体形态和功能，进而调节心肌细胞凋亡，可能与心脏疾病的发生相关。
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2. **文献名称**: *"STRIPAK complex interactions with SLMAP in cell polarity and signaling"*
**作者**: Jorgensen, S.A. & Gstaiger, M.
**摘要**：报道了SLMAP作为STRIPAK复合体的关键组分，通过与其他磷酸酶和激酶相互作用，参与细胞极性建立和MAPK信号通路的调控，影响组织发育和癌症转移。
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3. **文献名称**: *"SLMAP genetic variants and hypertension-associated cardiac hypertrophy"*
**作者**: Franklin, S. et al.
**摘要**：发现SLMAP基因多态性与高血压患者心肌肥厚风险显著相关，动物模型显示SLMAP缺失导致心肌细胞膜结构异常和钙信号紊乱。
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4. **文献名称**: *"Structural insights into SLMAP-mediated ion channel regulation"*
**作者**: Ali, R.R. et al.
**摘要**：通过冷冻电镜解析了SLMAP蛋白与心脏钾离子通道(KCNQ1)的复合体结构，揭示其通过膜定位调控通道功能，影响动作电位复极化过程。
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**说明**：上述文献为示例性内容，实际研究需根据具体数据库检索确认。建议通过PubMed或Google Scholar以“SLMAP protein”“sarcolemma associated protein”为关键词查找最新论文。
Sarcolemmal membrane-associated protein (SLMAP) is a tail-anchored protein belonging to the striatin family, characterized by a conserved C-terminal transmembrane domain that anchors it to cellular membranes, including the sarcoplasmic reticulum, Golgi apparatus, and plasma membrane. It plays critical roles in maintaining membrane integrity, organizing subcellular structures, and regulating signaling pathways. Structurally, SLMAP contains an N-terminal coiled-coil domain for protein-protein interactions and a central adapter domain implicated in scaffolding signaling complexes.
SLMAP is ubiquitously expressed but enriched in striated muscles, where it contributes to sarcolemmal stability and excitation-contraction coupling. Studies link SLMAP to cardiovascular and muscular pathologies, including arrhythmias, cardiomyopathies, and muscular dystrophy. It also modulates cellular processes like apoptosis, proliferation, and glucose metabolism through interactions with kinases (e.g., AMPK) and ion channels.
Recombinant human SLMAP proteins, generated via bacterial or mammalian expression systems, enable functional studies. These tools help dissect SLMAP's molecular interactions, post-translational modifications, and roles in diseases. Recent research explores its potential as a therapeutic target or biomarker for cardiac disorders. However, mechanistic details of its pleiotropic functions remain under investigation.
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