关键信息
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基因名
SHCBP1
- 应用
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别名
FLJ22009; PAL; Protein expressed in Activated Lymphocytes; SHC binding and spindle associated 1; SHC SH2 domain-binding protein 1; SHCBP_HUMAN; Shcbp1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NEM2
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表达区间
2-672 aa
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氨基酸序列
ADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK WNGKGSFGTF LF
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分子量
75.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SHCBP1 (SHC SH2 domain-binding protein 1) has emerged as a significant player in various cellular processes, including signal transduction, cell proliferation, and apoptosis. This protein acts as a crucial adapter in the pathways mediated by receptor tyrosine kinases (RTKs), facilitating the interaction between signaling molecules and downstream effectors. Research has indicated that SHCBP1 is involved in the modulation of critical pathways such as the MAPK and PI3K/Akt pathways, which are vital for cell growth and survival. Abnormal expression or mutations in SHCBP1 have been associated with several malignancies, suggesting its potential role as a biomarker for cancer diagnosis and prognosis. Furthermore, its interaction with other proteins implicates it in broader regulatory networks that govern cellular responses to external stimuli. Given the importance of SHCBP1 in oncogenesis and other pathological conditions, recombinant SHCBP1 protein is valuable for understanding its molecular mechanisms, studying protein-protein interactions, and exploring its potential as a therapeutic target. Researchers are keen to delve deeper into the functions of SHCBP1 in various cellular contexts, aiming to elucidate its role in disease and potentially develop novel therapeutic strategies.
