| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF610 |
| Uniprot No | Q8N9Z0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-419 aa |
| 活性数据 | MLCDEEAQKRKAKESGMALPQGRLTFMDVAIEFSQEEWKSLDPGQRALYRDVMLENYRNLVFLGRSCVLGSNAENKPIKNQLGLTLESHLSELQLFQAGRKIYRSNQVEKFTNHRSSVSPLQKISSSFTTHIFNKYRNDLIDFPLLPQEEKAYIRGKSYEYECSEDGEVFRVPASLTNHQVIHTAEKPYKCTECGKVFSRNSHLVEHWRIHTGQKPYKCSECDKVFNRNSNLARHQRIHTGEKPHKCNECGKAFRECSGLTTHLVIHTGEKPYKCNECGKNFRHKFSLTNHQRSHTAEKPYKCNECGKVFSLLSYLARHQIIHSTEKPYKCNECGRAFHKRPGLMAHLLIHTGEKPYKCNECDKVFGRKLYLTNHQRIHTGERPYKCNACGKVFNQNPHLSRHRKIHAGENSLRTLQME |
| 分子量 | 75 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇涉及人ZNF610蛋白功能或相关研究的参考文献(文献为示例性内容，实际研究中需根据具体需求检索最新文献)：
1. **文献名称**：*ZNF610 regulates the proliferation and differentiation of neural stem cells through histone deacetylase recruitment*
**作者**：Wang L, et al.
**摘要**：该研究发现ZNF610作为C2H2型锌指蛋白，通过结合特定基因启动子区域并招募组蛋白去乙酰化酶(HDACs)，抑制神经干细胞的增殖并促进其分化，提示其在神经发育中的表观遗传调控作用。
2. **文献名称**：*Comprehensive analysis of zinc finger proteins in human genome reveals ZNF610 as a potential oncogene in colorectal cancer*
**作者**：Chen X, et al.
**摘要**：通过生物信息学筛选和功能验证，发现ZNF610在结直肠癌组织中高表达，并通过调控Wnt/β-catenin信号通路促进肿瘤细胞侵袭，其重组蛋白过表达显著增强体外癌细胞的迁移能力。
3. **文献名称**：*Structural characterization of recombinant human ZNF610 elucidates DNA-binding specificity*
**作者**：Zhang Y, et al.
**摘要**：通过重组表达纯化人ZNF610蛋白，结合X射线晶体学揭示了其锌指结构域与特定DNA序列(5'-GCCATC-3')的结合模式，为解析其转录调控机制提供了结构基础。
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**提示**：若需获取真实文献，建议在PubMed或Google Scholar中使用关键词“ZNF610”、“zinc finger protein 610”结合研究领域(如“cancer”、“epigenetics”)检索，并优先选择近5年的高被引论文。
Zinc finger protein 610 (ZNF610) is a member of the Krüppel-associated box (KRAB)-containing zinc finger protein family, a large group of transcription factors implicated in transcriptional regulation and chromatin remodeling. Characterized by tandem C2H2-type zinc finger domains, ZNF610 binds to specific DNA sequences to modulate gene expression, often through its N-terminal KRAB domain, which recruits co-repressors like KAP1 to establish repressive chromatin states. While its exact biological roles remain under investigation, ZNF610 is hypothesized to participate in cellular processes such as differentiation, proliferation, and apoptosis. Studies suggest potential links to developmental regulation and disease pathways, including cancer and neurodegenerative disorders, though mechanistic insights are limited.
Recombinant human ZNF610 protein, produced via heterologous expression systems (e.g., E. coli, mammalian cells), enables functional studies by providing a purified, bioactive form of the protein. This tool facilitates in vitro assays to map DNA-binding motifs, identify interacting partners, and explore its regulatory targets. Emerging evidence also implicates ZNF610 in epigenetic silencing and retroelement suppression, aligning with broader roles of KRAB-ZNFs in genome stability and host defense. However, challenges persist in unraveling its tissue-specific activities and context-dependent interactions. Further research using recombinant ZNF610 could clarify its pathophysiological relevance, offering potential avenues for therapeutic intervention in diseases linked to aberrant transcriptional control.
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