关键信息
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基因名
ABCC10
- 应用
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别名
ABCC10；MRP7；SIMRP7；ATP-binding cassette sub-family C member 10
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T3U5
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ABCC10 (ATP-binding cassette sub-family C member 10) is a crucial protein associated with multidrug resistance in cancer therapy. As a member of the ATP-binding cassette (ABC) transporters, ABCC10 functions primarily as a transporter that mediates the efflux of various substrates, including chemotherapeutic agents. Its role in drug resistance makes it a significant focus of cancer research, particularly in understanding how tumors evade the effects of chemotherapy. Overexpression of ABCC10 has been linked to reduced efficacy of numerous anticancer drugs, impacting treatment outcomes for patients. Additionally, ABCC10 is involved in the transport of endogenous compounds and metabolites, highlighting its importance in both pharmacokinetics and cellular homeostasis. Investigating the structural and functional properties of ABCC10 through recombinant protein studies offers insights into its mechanistic roles, substrate specificity, and potential as a therapeutic target. Advances in producing and characterizing recombinant ABCC10 can aid in the development of inhibitors to counteract drug resistance, thereby enhancing the effectiveness of existing therapies. Understanding the biochemical pathways and interactions of ABCC10 may ultimately lead to novel strategies for improving cancer treatment and overcoming therapeutic challenges presented by multidrug-resistant cancer cells.
