关键信息
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基因名
FKBP8
- 应用
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别名
FKBP8；FKBP38；Peptidyl-prolyl cis-trans isomerase FKBP8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14318
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表达区间
1-412aa
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氨基酸序列
MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQ PPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKG QVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYG PQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLA ANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLE HQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTE TALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
FKBP8 (FK506-binding protein 8) is a member of the FKBP family of proteins, known for their prolyl isomerase activity and involvement in various cellular processes, including protein folding, trafficking, and regulation of apoptosis. Its role as a chaperone in the endoplasmic reticulum has attracted significant attention due to its association with numerous pathological conditions, including cancer and neurodegenerative diseases. The significance of FKBP8 is underscored by its regulation of protein homeostasis and its potential interaction with key signaling pathways, such as the mTOR pathway, which is critical for cell growth and metabolism. Additionally, FKBP8 has been implicated in the modulation of immune responses, particularly in T-cell activation and differentiation. As a result, recombinant FKBP8 protein has become a focal point for research aimed at understanding its functional properties, elucidating its role in disease mechanisms, and exploring its potential as a therapeutic target. Through the generation and characterization of recombinant FKBP8, researchers can investigate its structure-function relationships, develop inhibitors, and assess its therapeutic application in various disorders, thereby contributing to the advancement of targeted therapies in clinical settings.
