关键信息
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基因名
NKRF
- 应用
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别名
NKRF；ITBA4；NRF；NF-kappa-B-repressing factor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15226
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表达区间
1-690aa
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氨基酸序列
MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSK FHARPRFEPVHFVASSSKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDY TQDSFSIQDGNSQYCDSSGFILTKDQPVTANMYFDSGNPAPSTTSQQANS QSTPEPSPSQTFPESVVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYT YMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIY LTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQI GMSSYEFPPALKQPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAI GILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHA AADEALKILQKTQPTYPSVKSSQCHTGSSPRGSGKKKDIKDLVVYENSSN PVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVK YEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIK EDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNK IAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLKSKSH GVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN
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分子量
104 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NKRF (Nuclear factor Kappa B Repressor Factor) is a transcriptional regulator known for its role in modulating immune responses and apoptosis. Recent studies have highlighted its significance in various pathological conditions, including cancer, autoimmune diseases, and inflammatory disorders. Research on NKRF is crucial because it serves as a negative regulator of NF-κB signaling pathways, which are fundamental in cell survival, proliferation, and the inflammatory response. Dysregulation of NKRF can lead to uncontrolled NF-κB activity, contributing to the progression of diseases such as tumors and chronic inflammatory conditions. The focus on NKRF recombinant protein endeavors to elucidate its functional mechanisms and potential therapeutic applications. By producing NKRF in a recombinant form, researchers aim to investigate its interactions with other cellular factors and its impact on gene expression. This exploration could unveil new avenues for targeted therapies, potentially allowing for novel interventions in diseases characterized by NF-κB overactivation. Overall, the study of NKRF recombinant protein is warranted as it not only enhances our understanding of immune regulation but also opens up possibilities for innovative treatment strategies in various disease contexts.
