关键信息
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基因名
HAUS7
- 应用
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别名
HAUS7；UCHL5IP；UIP1；HAUS augmin-like complex subunit 7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99871
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表达区间
1-368aa
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氨基酸序列
MGGARLGARN MAGQDAGCGR GGDDYSEDEG DSSVSRAAVE VFGKLKDLNC PFLEGLYITE PKTIQELLCS PSEYRLEILE WMCTRVWPSL QDRFSSLKGV PTEVKIQEMT KLGHELMLCA PDDQELLKGC ACAQKQLHFM DQLLDTIRSL TIGCSSCSSL MEHFEDTREK NEALLGELFS SPHLQMLLNP ECDPWPLDMQ PLLNKQSDDW QWASASAKSE EEEKLAELAR QLQESAAKLH ALRTEYFAQH EQGAAAGAAD ISTLDQKLRL VTSDFHQLIL AFLQVYDDEL GECCQRPGPD LHPCGPIIQA THQNLTSYSQ LLQVVMAVAD TSAKAVETVK KQQGEQICWG GSSSVMSLAT KMNELMEK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
HAUS7 is a key protein involved in the assembly and functionality of the microtubule organizing center, specifically within the context of the HUS1 complex, which plays a crucial role in cell division and the maintenance of genomic stability. Recent studies have highlighted its importance not only in the mitotic spindle assembly and positioning but also in response to cellular stress and DNA damage repair mechanisms. The HAUS complex, comprising several subunits including HAUS7, is essential for the proper organization of microtubules during mitosis, influencing processes such as chromosome segregation and spindle dynamics. Dysregulation of HAUS7 and associated proteins has been linked to various oncogenic pathways, suggesting its potential role as a therapeutic target in cancer treatment. Consequently, understanding the structure, function, and regulatory mechanisms of HAUS7 is crucial for elucidating its contribution to cellular processes and disease states. Research in this area aims to develop novel strategies for targeting HAUS7 in cancer therapy, as well as to advance our knowledge of microtubule dynamics and its implications in cellular function and stability.
