关键信息
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基因名
DEFB136
- 应用
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别名
beta 136; Beta-defensin 136; DB136_HUMAN; DEFB136; Defensin
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q30KP8
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表达区间
1-77aa
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氨基酸序列
MATRSVLLALVVLNLLFYVPPGRSGPNVYIQKIFASCWRLQGTCRPKCLKNEQYRILCDTIHLCCVNPKYLPILTGK
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分子量
35.42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
DEFB136 is a member of the beta-defensin family, which comprises small, cationic peptides known for their antimicrobial properties and role in the immune response. Research into DEFB136 has gained interest due to its potential involvement in innate immunity, particularly concerning host defense against various pathogens. The protein is predominantly expressed in epithelial tissues, suggesting a critical function in frontline defense mechanisms. Furthermore, studies have indicated that DEFB136 may play a role in modulation of the inflammatory response, which is vital for maintaining homeostasis during infections or tissue injury. Genetic analyzes have also shown variations in the DEFB136 gene that could impact susceptibility to infections and inflammatory diseases. Therefore, understanding the structure, function, and regulation of DEFB136 is vital not only for elucidating its role in the immune system but also for potential therapeutic applications, such as designing new antimicrobial agents or understanding autoimmune disorders. Advances in recombinant protein technology have facilitated the production and study of DEFB136, paving the way for further investigations into its functional properties and clinical significance. Harnessing the unique features of DEFB136 may provide new insights into therapeutic strategies that leverage innate immunity.
