关键信息
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基因名
ST8SIA3
- 应用
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别名
ST8SIA3; SIAT8C; Sia-alpha-2.3-Gal-beta-1.4-GlcNAc-R:alpha 2.8-sialyltransferase; Alpha-2.8-sialyltransferase 8C; Alpha-2.8-sialyltransferase III; ST8 alpha-N-acetyl-neuraminide alpha-2.8-sialyltransferase 3; Sialyltransferase 8C; SIAT8-C; Sialyltransferase St8Sia III; ST8SiaIII
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43173
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表达区间
1-380 aa
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氨基酸序列
MRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQFALKFLDPSFVPITNSLTQELQEKPSKWKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA
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分子量
70.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The ST8SIA3 protein, part of the ST8SIA gene family, is a significant player in the biosynthesis of polysialic acid, which is known to influence cell-cell interactions during neurodevelopment and in various pathological conditions. Alterations in polysialic acid expression, mediated by ST8SIA3, have been linked to neurodevelopmental disorders, including schizophrenia and autism spectrum disorders, as well as to tumor progression in certain cancers. Recent studies have highlighted the importance of this protein in modulating synaptic plasticity and neuronal migration, suggesting that it plays a critical role in brain development and function. As research advances, the potential of ST8SIA3 as a therapeutic target in neurodevelopmental and oncological contexts is also gaining attention. Understanding the structure and function of the ST8SIA3 recombinant protein could pave the way for innovative strategies in treating disorders associated with its dysregulation, making it a focal point of biomedical research.
