关键信息
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基因名
SUPT6H
- 应用
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别名
SUPT6H；KIAA0162；SPT6H；Transcription elongation factor SPT6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7KZ85
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SUPT6H is a vital protein involved in the regulation of transcription and chromatin dynamics. As a member of the SUPT6 family, it plays a critical role in maintaining RNA polymerase II activity, assisting in the elongation phase of transcription, and facilitating the proper processing of nascent RNA. Recent studies have highlighted its significance not only in normal cellular processes but also in various disease states, including cancer. Given its central role in gene expression regulation, understanding the structural and functional aspects of SUPT6H is crucial. This encompasses the exploration of its interactions with other transcription factors and chromatin modifiers, as well as the elucidation of its impact on gene integrity and expression levels. Advances in recombinant protein technology allow for the overproduction and purification of SUPT6H, enabling detailed biochemical and biophysical analyses. Such studies can reveal insights into its mechanism of action, potential post-translational modifications, and its involvement in complex biological pathways. Therefore, research on SUPT6H not only contributes to our knowledge of transcriptional regulation but also presents potential therapeutic targets for diseases arising from dysregulation of gene expression.
