关键信息
-
基因名
SYT7
- 应用
-
别名
SYT7; PCANAP7; Synaptotagmin-7; IPCA-7; Prostate cancer-associated protein 7; Synaptotagmin VII; SytVII
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O43581
-
表达区间
41-139 aa
-
氨基酸序列
CQRKLGKRYKNSLETVGTPDSGRGRSEKKAIKLPAGGKAVNTAPVPGQTPHDESDRRTEPRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRI
-
分子量
36.63kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SYT7, or synaptotagmin 7, is a member of the synaptotagmin family of proteins, which play crucial roles in neurotransmitter release and synaptic transmission. Recent research has highlighted its importance in calcium-dependent exocytosis, a fundamental process in neuronal communication. Unlike other synaptotagmins that primarily function in synaptic vesicle release, SYT7 is implicated in the regulation of late endocytic and secretory pathways and may interact with different types of membrane traffic beyond the synapse, such as in the release of hormones and other bioactive substances. Studies have indicated that SYT7 could be a key player in various physiological processes and pathophysiological conditions, including neurodegenerative diseases, given its involvement in vesicle trafficking. Understanding the structure and function of the SYT7 protein is essential for elucidating its role in cellular mechanisms and could potentially lead to novel therapeutic targets for treating disorders related to impaired synaptic transmission. Therefore, the characterization of recombinant SYT7 protein is pivotal in providing insights into its molecular mechanisms, interactions, and overall contributions to cellular signaling pathways. This research not only advances our understanding of synaptic physiology but also opens avenues for exploring its implications in broader biomedical contexts.
