关键信息
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基因名
WDR5B
- 应用
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别名
WDR5BWD repeat-containing Protein 5B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86VZ2
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表达区间
1-330 aa
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氨基酸序列
MATKESRDAK AQLALSSSAN QSKEVPENPN YALKCTLVGH TEAVSSVKFS PNGEWLASSS ADRLIIIWGA YDGKYEKTLY GHNLEISDVA WSSDSSRLVS ASDDKTLKLW DVRSGKCLKT LKGHSNYVFC CNFNPPSNLI ISGSFDETVK IWEVKTGKCL KTLSAHSDPV SAVHFNCSGS LIVSGSYDGL CRIWDAASGQ CLKTLVDDDN PPVSFVKFSP NGKYILTATL DNTLKLWDYS RGRCLKTYTG HKNEKYCIFA NFSVTGGKWI VSGSEDNLVY IWNLQTKEIV QKLQGHTDVV ISAACHPTEN LIASAALEND KTIKLWMSNH
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分子量
36.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
WDR5B, a member of the WD repeat protein family, has garnered attention in recent years due to its critical role in various cellular processes, particularly in the regulation of gene expression and chromatin remodeling. It acts as a crucial component of the MLL (mixed-lineage leukemia) complex, which is involved in histone methylation, thus influencing transcriptional activation of target genes. Dysregulation of WDR5B has been implicated in several cancers and developmental disorders, making it a significant focus of research. The recombinant expression of WDR5B allows researchers to study its structure and function, providing insights into its interaction with other proteins and its involvement in epigenetic modifications. Understanding WDR5B’s mechanisms could yield novel therapeutic targets for diseases associated with its dysfunction, such as leukemia. Consequently, efforts to produce WDR5B as a recombinant protein are critical in advancing our knowledge of its biological functions and its potential implications in disease pathology.
