关键信息
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基因名
FBXL21
- 应用
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别名
F box and leucine rich repeat protein 21; F box and leucine rich repeat protein 3 pseudogene; F box and leucine rich repeat protein 3B; F box protein Fbl3b; F box/LRR repeat protein 21; F box/LRR repeat protein 3B; F-box and leucine-rich repeat protein 21
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKT6
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表达区间
1-434aa
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氨基酸序列
F box and leucine rich repeat protein 21; F box and leucine rich repeat protein 3 pseudogene; F box and leucine rich repeat protein 3B; F box protein Fbl3b; F box/LRR repeat protein 21; F box/LRR repeat protein 3B; F-box and leucine-rich repeat protein 21
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分子量
49.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
FBXL21 is an important member of the F-box protein family, which plays a critical role in the ubiquitin-proteasome system (UPS), a key regulatory mechanism for protein degradation in eukaryotic cells. This protein is primarily involved in the recognition and subsequent ubiquitination of specific substrates, influencing various cellular processes such as cell cycle progression, signal transduction, and stress responses. Research has indicated that FBXL21 may have implications in several diseases, including cancer, as dysregulation of the UPS can lead to aberrant protein accumulation and cellular dysfunction. Additionally, FBXL21 is known to interact with various signaling pathways and proteins, emphasizing its potential role in maintaining cellular homeostasis. Recent studies have focused on the structural characterization and functional analysis of FBXL21, aiming to elucidate its substrate specificity and regulatory mechanisms within the UPS. By understanding the functional dynamics of FBXL21 and its involvement in ubiquitination processes, researchers hope to uncover novel therapeutic targets for diseases linked to UPS abnormalities, paving the way for advancements in targeted molecular therapies. This growing interest in FBXL21 underscores the need for continued exploration of its biological functions and potential applications in medicine.
