关键信息
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基因名
NURR1
- 应用
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别名
NURR1；NOT；NURR1；TINUR；Nuclear receptor subfamily 4 group A member 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43354
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表达区间
1-598aa
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氨基酸序列
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTE ITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNY QQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLH NFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHV PMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPS PPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCL ANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPK SPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDT QHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLR LAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDI SAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPN YLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
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分子量
69 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NURR1, a nuclear receptor and member of the nuclear receptor superfamily, plays a crucial role in the development and maintenance of dopaminergic neurons in the midbrain, as well as in the regulation of various neurobiological processes. Due to its significant involvement in neurodevelopmental and neurodegenerative disorders, particularly Parkinson's disease, NURR1 has garnered considerable interest in the scientific community. The understanding of its biological functions and mechanism of action has led to the exploration of NURR1 as a potential therapeutic target for neurodegenerative diseases. Research has indicated that NURR1 contributes to neuronal survival and inflammation modulation, which are vital for maintaining dopamine homeostasis and preventing neuronal cell death. The production of recombinant NURR1 protein is essential for studying its structure-function relationships and for screening small molecules that may enhance its activity. Moreover, investigating NURR1's interactions with other proteins and its downstream signaling pathways may provide insights into its regulatory roles in gene expression and neural plasticity. As a result, the reconstitution of NURR1 as a recombinant protein serves both as a foundational tool for understanding its function at the molecular level and as a potential means of developing novel therapeutic strategies to combat diseases associated with dopaminergic dysfunction.
