关键信息
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基因名
UBE2V1
- 应用
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别名
CIR1; CROC-1; CROC1; CROC1A; TRAF6-regulated IKK activator 1 beta Uev1A; UB2V1_HUMAN; UBE2V 1; UBE2V; UBE2V1; Ubiquitin conjugating enzyme E2 variant 1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; UEV1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13404
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表达区间
2-147 aa
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氨基酸序列
AATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG MIIGPPRTIY ENRIYSLKIE CGPKYPEAPP FVRFVTKINM NGVNSSNGVV DPRAISVLAK WQNSYSIKVV LQELRRLMMS KENMKLPQPP EGQCYSN
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分子量
16.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
UBE2V1, a member of the ubiquitin-conjugating enzyme family, plays a crucial role in the ubiquitin-proteasome system, which is essential for protein degradation, cell cycle regulation, and various cellular processes. This enzyme is particularly noted for its involvement in the modification of target proteins with ubiquitin chains, influencing their stability and function. The study of UBE2V1 has gained significant attention due to its implications in various diseases, including cancer, where aberrations in ubiquitination processes can lead to oncogenesis and tumor progression. Understanding UBE2V1's specific interactions and regulatory mechanisms is vital for elucidating its role in cellular homeostasis and disease pathogenesis. Moreover, the development of UBE2V1 as a potential therapeutic target presents exciting opportunities for novel treatments, as modulating its activity may restore normal protein turnover and cellular function. Recombinant UBE2V1 protein has become a valuable tool for investigating the enzyme's biochemical properties and its interactions with other components of the ubiquitin pathway, providing insights into the molecular underpinnings of its function and its broader implications in human health and disease. As research continues to unfold, UBE2V1 stands at the intersection of fundamental biology and translational medicine, highlighting the importance of this enzyme in both basic and applied science.
