关键信息
-
基因名
PER2
- 应用
-
别名
PER2；KIAA0347；Period circadian Protein homolog 2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O15055
-
表达区间
1-100aa
-
氨基酸序列
MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTG RDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSD
-
分子量
37 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The research on the PER2 recombinant protein stems from the growing interest in circadian rhythms and their impact on various physiological processes. PER2, or Period2, is a core component of the circadian clock, which regulates the timing of biological activities in response to environmental cues. Disturbances in circadian rhythms have been linked to numerous health issues, including sleep disorders, metabolic syndromes, and even certain cancers. By expressing and purifying PER2 as a recombinant protein, researchers aim to gain insights into its structural properties, interaction with other clock proteins, and regulatory mechanisms. This approach allows for detailed studies using biochemical assays and structural biology techniques, enabling a better understanding of how PER2 influences molecular circadian regulation. Furthermore, understanding the functional dynamics of PER2 can potentially lead to therapeutic strategies for managing circadian-related disorders, offering avenues for innovative treatments and enhancing overall health outcomes. Thus, studying the recombinant form of PER2 is crucial for unraveling the complexities of circadian biology and its relevance to human health.
