关键信息
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基因名
UNC84B
- 应用
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别名
SUN2; FRIGG; KIAA0668; RAB5IP; UNC84B; SUN domain-containing Protein 2; Protein unc-84 homolog B; Rab5-interacting Protein; Rab5IP; Sad1/unc-84 Protein-like 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UH99
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表达区间
1-717 aa
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氨基酸序列
MSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGPSSDAHTSYYSESLVHESWFPPRSSLEELHGDANWGEDLRVRRRRGTGGSESSRASGLVGRKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRSAVSRAGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLLPLLLLTCLTYGAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWEARDSSPHFQAEQRVMSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLARGGGGRVGLLQREEMQAQLRELESKILTHVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHFQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH
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分子量
105.27 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
UNC84B, a member of the UNC84 family of proteins, has garnered significant attention in recent years due to its involvement in various cellular processes, particularly in the realm of cellular transport and intracellular signaling. Originally identified in studies focusing on cellular morphology and migration in model organisms such as *Caenorhabditis elegans*, UNC84B has emerged as a crucial player in the functioning of the nuclear envelope and its interactions with the cytoskeleton. Research has indicated that UNC84B is integral to the proper localization of nuclear components and plays a role in maintaining nuclear structure, thereby influencing gene expression and cellular responses to environmental cues. Moreover, its association with diseases such as muscular dystrophy and certain cancers highlights its potential as a therapeutic target. The recombinant production of UNC84B facilitates detailed studies of its structural and functional properties, allowing researchers to dissect its mechanisms of action and interactions with other cellular proteins. Understanding the biophysical characteristics and biological roles of UNC84B can provide insights into fundamental cellular processes and contribute to the development of novel strategies for addressing related pathologies. Overall, UNC84B represents a significant focus of research in cell biology, with implications reaching far beyond its initial characterization, pointing towards its potential impact in therapeutic applications and disease prevention.
