关键信息
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基因名
UTP6
- 应用
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别名
UTP6; C17orf40; HCA66; MHAT; U3 small nucleolar RNA-associated Protein 6 homolog; Hepatocellular carcinoma-associated antigen 66; Multiple hat domains Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NYH9
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表达区间
2-597 aa
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氨基酸序列
AEIIQERIE DRLPELEQLE RIGLFSHAEI KAIIKKASDL EYKIQRRTLF KEDFINYVQY EINLLELIQR RRTRIGYSFK KDEIENSIVH RVQGVFQRAS AKWKDDVQLW LSYVAFCKKW ATKTRLSKVF SAMLAIHSNK PALWIMAAKW EMEDRLSSES ARQLFLRALR FHPECPKLYK EYFRMELMHA EKLRKEKEEF EKASMDVENP DYSEEILKGE LAWIIYKNSV SIIKGAEFHV SLLSIAQLFD FAKDLQKEIY DDLQALHTDD PLTWDYVARR ELEIESQTEE QPTTKQAKAV EVGRKEERCC AVYEEAVKTL PTEAMWKCYI TFCLERFTKK SNSGFLRGKR LERTMTVFRK AHELKLLSEC QYKQLSVSLL CYNFLREALE VAVAGTELFR DSGTMWQLKL QVLIESKSPD IAMLFEEAFV HLKPQVCLPL WISWAEWSEG AKSQEDTEAV FKKALLAVIG ADSVTLKNKY LDWAYRSGGY KKARAVFKSL QESRPFSVDF FRKMIQFEKE QESCNMANIR EYYERALREF GSADSDLWMD YMKEELNHPL GRPENCGQIY WRAMKMLQGE SAEAFVAKHA MHQTGHL
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分子量
70.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
UTP6 (U3 small nucleolar RNA-associated protein 6) is a key player in the biogenesis of ribosomes, essential for cellular function and growth. Research into UTP6 has gained momentum due to its involvement in the assembly of the small nucleolar ribonucleoprotein complexes that facilitate pre-rRNA processing. Mutations in UTP6 have been implicated in various diseases, including cancers and developmental disorders, highlighting its relevance in human health. The protein is part of a larger network of proteins and RNA that cooperate in the modification and processing of rRNA transcripts. This intricate mechanism underscores the importance of UTP6 in cellular homeostasis and gene expression. Recent studies using advanced techniques such as cryo-electron microscopy and X-ray crystallography have elucidated the structural and functional characteristics of UTP6, paving the way for potential therapeutic interventions targeting its pathways. Understanding the precise role of UTP6 in ribosome biogenesis not only contributes to our knowledge of fundamental cellular processes but also opens avenues for addressing the pathological conditions associated with its dysfunction. Given the critical nature of ribosome assembly in cellular physiology, ongoing research into UTP6 may provide insights into novel treatments for diseases linked to ribosomal dysregulation.
