关键信息
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基因名
SLC16A4
- 应用
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别名
SLC16A4; MCT4; MCT5
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种属
Human
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表达系统
E. coli
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标签
N-terminal His and TRxA Tag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15374
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表达区间
1-487aa
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氨基酸序列
MLKREGKVQP YTKTLDGGWG WMIVIHFFLV NVFVMGMTKT FAIFFVVFQE EFEGTSEQIG WIGSIMSSLR FCAGPLVAII CDILGEKTTS ILGAFVVTGG YLISSWATSI PFLCVTMGLL PGLGSAFLYQ VAAVVTTKYF KKRLALSTAI ARSGMGLTFL LAPFTKFLID LYDWTGALIL FGAIALNLVP SSMLLRPIHI KSENNSGIKD KGSSLSAHGP EAHATETHCH ETEESTIKDS TTQKAGLPSK NLTVSQNQSE EFYNGPNRNR LLLKSDEESD KVISWSCKQL FDISLFRNPF FYIFTWSFLL SQLAYFIPTF HLVARAKTLG IDIMDASYLV SVAGILETVS QIISGWVADQ NWIKKYHYHK SYLILCGITN LLAPLATTFP LLMTYTICFA IFAGGYLALI LPVLVDLCRN STVNRFLGLA SFFAGMAVLS GPPIAGWLYD YTQTYNGSFY FSGICYLLSS VSFFFVPLAE RWKNSLT
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分子量
49.1kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SLC16A4, also known as the monoamine transporter, is a member of the solute carrier family that primarily transports neurotransmitters such as serotonin, dopamine, and other monoamines. Research on SLC16A4 has gained prominence due to its critical role in neurotransmitter homeostasis, which is pivotal for maintaining emotional balance and cognitive functions. Disruptions in the transport function of SLC16A4 have been implicated in various psychiatric disorders, including depression and anxiety, making it a potential therapeutic target. The recombinant protein of SLC16A4 offers a valuable tool for studying its structure-function relationships, cellular localization, and transport mechanisms. By expressing this protein in various model systems, researchers can investigate the effects of genetic variations on its activity and explore the influence of various substrates and inhibitors. Understanding the biochemical properties and regulatory pathways of SLC16A4 will contribute to a better understanding of its physiological roles and the pathophysiology of related disorders. Furthermore, insights gained from recombinant SLC16A4 research may guide the development of novel pharmacological agents aimed at modulating its activity, thereby advancing treatment strategies for mental health conditions associated with dysregulated monoamine transport.
