Cat: PA2000-7838

Recombinant Human FRG1 Protein,GST

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关键信息

  • 基因名

    FRG1

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    frg1; FRG1_HUMAN; FRG1A; FSG1; FSHD region gene 1 protein; Protein FRG1

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    GST-tag at N-terminal

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q14331

  • 表达区间

    1-258aa

  • 氨基酸序列

    MAEYSYVKSTKLVLKGTKTKSKKKKSKDKKRKREEDEETQLDIVGIWWTVTNFGEISGTIAIEMDKGTYIHALDNGLFTLGAPHKEVDEGPSPPEQFTAVKLSDSRIALKSGYGKYLGINSDGLVVGRSDAIGPREQWEPVFQNGKMALLASNSCFIRCNEAGDIEAKSKTAGEEEMIKIRSCAERETKKKDDIPEEDKGNVKQCEINYVKKFQSFQDHKLKISKEDSKILKKARKDGFLHETLLDRRAKLKADRYCK

  • 分子量

    54.12 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

FRG1, or Farnesylated Rab GTPase 1, is a protein that has gained attention in recent years due to its association with certain biological processes and diseases. Initially identified in studies related to muscle development and function, FRG1 is believed to play a crucial role in signaling pathways that govern cell growth, differentiation, and survival. Research indicates that mutations or dysregulation of FRG1 may contribute to pathological conditions, particularly in neuromuscular disorders such as facioscapulohumeral muscular dystrophy (FSHD). The exploration of FRG1 as a recombinant protein has opened avenues for understanding its structure-function relationships, interaction with other cellular components, and its potential role in therapeutic interventions. By utilizing techniques in protein engineering and molecular biology, researchers aim to elucidate the mechanistic underpinnings of FRG1's action, providing insights that could lead to novel treatments for diseases linked to its dysfunction. The recombinant expression of FRG1 also enables the development of high-throughput screening assays, facilitating the discovery of small molecules or biologics that may modulate its activity. As the scientific community continues to uncover the complexities surrounding FRG1, its significance in both basic research and clinical applications becomes increasingly evident, marking it as a critical focus in the field of molecular biology and medicine.

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