关键信息
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基因名
ADAMTS1
- 应用
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别名
ADAMTS1；KIAA1346；METH1；A disintegrin and metalloProteinase with thrombospondin motifs 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHI8
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表达区间
253-616aa
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氨基酸序列
FVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSV SLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDT AILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHE LGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMIT SFLDNGHGECLMDKPHNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDA ASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRK HFDTPFHGNWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKR VRYRSCNLEDCPDN(H)6
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分子量
41 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ADAMTS1 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 1) is a member of the ADAMTS family, which plays critical roles in extracellular matrix (ECM) remodeling and is implicated in various physiological and pathological processes. It is primarily involved in the cleavage of aggrecan, a major component of cartilage, and has been associated with the regulation of angiogenesis and tumor progression. Studies have shown that ADAMTS1 expression is modulated in various diseases, including cancer, where it can influence tumor microenvironment and metastasis. Its dual role as both a promoter and inhibitor of angiogenesis highlights its potential as a therapeutic target. The recombinant protein form of ADAMTS1 is essential for investigating its functional roles, interactions with other ECM components, and potential as a biomarker. By producing ADAMTS1 in a recombinant manner, researchers can study its enzymatic activity, protein structure, and implications in disease models, paving the way for novel therapeutic strategies in cancer and other ECM-related disorders. Understanding the molecular mechanics of ADAMTS1 through recombinant protein studies may provide insights into its regulatory functions and therapeutic potential in modulating tissue repair and pathological conditions.
