关键信息
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基因名
GDDR
- 应用
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别名
BLOT; Blottin; BRICD1B; BRICHOS domain containing 1B; Down regulated in gastric cancer GDDR; Down-regulated in gastric cancer; Gastrokine-2; GDDR; Gkn2; GKN2_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86XP6
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表达区间
1-184aa
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氨基酸序列
MKILVAFLVVLTIFGIQSHGYEVFNIISPSNNGGNVQETVTIDNEKNTAIINIHAGSCSSTTIFDYKHGYIASRVLSRRACFILKMDHQNIPPLNNLQWYIYEKQALDNMFSSKYTWVKYNPLESLIKDVDWFLLGSPIEKLCKHIPLYKGEVVENTHNVGAGGCAKAGLLGILGISICADIHV
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分子量
46.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GDDR (G-quadruplex DNA-binding domain) proteins represent a fascinating area of research due to their unique ability to interact with G-quadruplex structures found in nucleic acids. These specialized DNA conformations, characterized by stacked guanine tetrads, are implicated in various biological processes, including gene regulation, telomere maintenance, and genome stability. Recent studies have unveiled that GDDR proteins play crucial roles in cellular mechanisms, influencing transcriptional regulation and participating in the DNA damage response. Dysregulation of these interactions is associated with several diseases, particularly cancer, where G-quadruplexes can affect the expression of oncogenes and tumor suppressor genes. The growing interest in GDDR proteins stems from the potential to exploit their binding properties for therapeutic applications. Small molecules that stabilize G-quadruplexes or modulate the activity of GDDR proteins are being investigated for their ability to selectively target cancer cells while sparing normal tissues. This research not only enhances our understanding of molecular biology but also opens avenues for innovative drug design, providing a promising strategy in the fight against cancer and other G-quadruplex-related disorders.
