关键信息
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基因名
GBP5
- 应用
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别名
GBP5；Guanylate-binding Protein 5
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种属
Human
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表达系统
E. coli
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标签
N-terminal His-Tag and GFP
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96PP8
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表达区间
1-586aa
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氨基酸序列
MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSVASTVQSHTKGIW IWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSP DLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFD LPAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLA LAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICK RNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAIL QTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAA QLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
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分子量
90kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GBP5 (Guanylate Binding Protein 5) is a member of the guanylate-binding protein family, which plays a crucial role in the immune response and inflammation. GBP5 is particularly significant due to its involvement in the host defense against viral and bacterial infections, as well as its role in regulating autophagy and cell signaling pathways. The protein exhibits GTPase activity, enabling it to hydrolyze GTP and participate in the formation of cellular structures that isolate pathogens. Research into GBP5 has gained momentum due to its potential implications in various diseases, including infections and inflammatory conditions. Moreover, understanding the structural and functional dynamics of GBP5 can facilitate the development of targeted therapies that harness its immune-modulatory properties. Investigating the mechanisms by which GBP5 is regulated and activates downstream effects could reveal new avenues for therapeutic intervention in immune-related disorders. As such, the study of GBP5 and its reorganization through recombinant protein techniques is pivotal in elucidating its role within the immune system and advancing medical research targeted at infectious diseases and inflammatory responses.
