Recombinant Human LARP1B protein

LARP1B (La-related protein 1B) is a member of the La-related protein family, which is evolutionarily conserved and characterized by RNA-binding motifs. It shares structural homology with the La protein, including a conserved La motif and adjacent RNA recognition motif (RRM), but exhibits distinct functional roles. LARP1B is primarily implicated in post-transcriptional gene regulation, including mRNA stability, translation, and RNA processing. Unlike its well-studied paralog LARP1. which regulates mTORC1-sensitive mRNAs, LARP1B remains less characterized, though emerging studies suggest its involvement in cellular stress responses and cancer progression.

Recombinant LARP1B protein is engineered for in vitro studies to elucidate its molecular interactions and biochemical properties. Produced via heterologous expression systems (e.g., E. coli or mammalian cells), it retains RNA-binding capacity and structural domains critical for function. Researchers utilize this tool to map RNA/protein interaction sites, assess its role in ribonucleoprotein complexes, and investigate its regulatory effects on target mRNAs. Dysregulation of LARP1B has been observed in cancers, with some evidence linking its expression to tumor suppression or oncogenesis, depending on cellular context. Its recombinant form enables mechanistic studies to resolve these conflicting observations.

Current research focuses on identifying LARP1B-associated RNAs (e.g., coding/non-coding RNAs) and pathways, particularly those related to cell cycle control and apoptosis. Its potential as a diagnostic biomarker or therapeutic target in diseases like colorectal or hepatocellular carcinoma is under exploration. However, functional redundancy within the LARP family and tissue-specific expression patterns complicate its characterization. Recombinant LARP1B serves as a foundational resource to address these knowledge gaps and advance understanding of RNA-binding proteins in health and disease.