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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FDCSP |
| Uniprot No | Q8NFU4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 18-85aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMGSFPVSQDQEREKRSISDSDELASGFFVF PYPYPFRPLPPIPFPRFPWFRRNFPIPIPESAPTTPLPSEK |
| 预测分子量 | 10 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于FDCSP(Follicular Dendritic Cell Secreted Protein)重组蛋白的模拟参考文献示例(文献为假设性概括，实际研究需通过学术数据库检索)：
1. **文献名称**: "Expression and Functional Characterization of Recombinant FDCSP in Immune Regulation"
**作者**: Smith A, et al.
**摘要**: 研究通过大肠杆菌系统成功表达重组FDCSP蛋白，验证其在体外调控B细胞活化和抗体分泌的功能，提示其在适应性免疫中的潜在作用。
2. **文献名称**: "Structural Analysis of FDCSP and Its Interaction with TLR4 in Chronic Inflammation"
**作者**: Chen L, et al.
**摘要**: 解析重组FDCSP的晶体结构，发现其通过结合Toll样受体4(TLR4)调控NF-κB通路，可能参与炎症性疾病的发生机制。
3. **文献名称**: "FDCSP as a Novel Biomarker in Autoimmune Disorders: Insights from Recombinant Protein-Based Assays"
**作者**: Tanaka K, et al.
**摘要**: 利用哺乳动物细胞表达的重组FDCSP建立ELISA检测方法，发现其在类风湿性关节炎患者血清中水平显著升高，或可作为疾病标志物。
4. **文献名称**: "Recombinant FDCSP Enhances Dendritic Cell Maturation and Antigen Presentation"
**作者**: Müller R, et al.
**摘要**: 研究证明重组FDCSP蛋白可促进树突状细胞成熟及T细胞活化，为基于FDCSP的疫苗佐剂开发提供实验依据。
**提示**：以上内容为模拟文献，实际研究中请通过PubMed、Web of Science等平台检索关键词“FDCSP recombinant”或结合具体研究领域(如免疫学、结构生物学)筛选近期论文。
FDCSP (Follicular Dendritic Cell Secreted Protein) is a relatively understudied protein initially identified in follicular dendritic cells (FDCs), specialized immune cells residing in lymphoid follicles. FDCs play critical roles in organizing lymphoid tissue microarchitecture and regulating B-cell activation during immune responses. FDCSP, encoded by the *FDCSP* gene, is a small secreted protein characterized by a conserved N-terminal domain and a C-terminal region rich in proline and serine residues, suggesting potential post-translational modifications. Though its precise biological function remains unclear, emerging evidence links FDCSP to immune regulation and inflammatory processes.
Recombinant FDCSP protein, produced via genetic engineering in systems like *E. coli* or mammalian cell cultures, enables functional studies by providing a purified, bioactive form of the protein. Researchers utilize it to investigate interactions with immune cells (e.g., B cells, T cells) and its role in modulating cytokine production, cell adhesion, or signaling pathways. Recent studies suggest FDCSP may influence autoimmune diseases, chronic inflammation, or tumor microenvironments, though mechanistic insights are still limited. Its recombinant form is also explored for potential therapeutic applications, such as immune modulation or targeted drug delivery.
Despite progress, key questions persist regarding FDCSP's receptor(s), signaling cascades, and tissue-specific functions. Ongoing research aims to clarify its physiological relevance and translational potential, leveraging recombinant protein tools to bridge molecular characterization with in vivo models. Further work is needed to define its role in health and disease, positioning FDCSP as an emerging candidate in immunology and biomedical research.
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