Recombinant Human STK32A protein

STK32A (Serine/Threonine Kinase 32A) is a member of the serine/threonine kinase family, which plays roles in cellular signaling pathways regulating processes like proliferation, differentiation, and apoptosis. Although less characterized than other kinases, STK32A has drawn attention due to its potential involvement in developmental and pathological conditions. Studies suggest it may influence cerebellar development and neuronal functions, with genetic variants linked to neurological disorders. Its expression patterns in tissues like the brain, testes, and kidneys hint at diverse physiological roles.

Recombinant STK32A protein is engineered in vitro using expression systems (e.g., E. coli, mammalian cells) to produce purified, functional kinase for research. This tool enables mechanistic studies, such as mapping enzymatic activity, substrate interactions, and regulatory domains. Researchers utilize it to investigate phosphorylation events, screen kinase inhibitors, or validate antibodies. Epitope tags (e.g., His, FLAG) are often incorporated to facilitate purification and detection. Challenges include preserving post-translational modifications, which may require eukaryotic expression systems. Current efforts focus on elucidating STK32A’s signaling networks and its implications in diseases like cancer or neurodegeneration. Its recombinant form accelerates target validation and drug discovery, bridging gaps between genomic data and therapeutic applications.