Mouse Monoclonal CK1 Antibody

CK1 antibodies are immunological tools designed to detect cytokeratin 1 (CK1), a member of the type II keratin family, which is part of the intermediate filament proteins crucial for maintaining epithelial cell structure and integrity. CK1 is primarily expressed in stratified epithelial tissues, such as the skin, esophagus, and cornea, often pairing with type I keratins (e.g., CK10) to form heteropolymers that provide mechanical resilience. These antibodies are widely used in research and diagnostics to study epithelial differentiation, tissue development, and pathological conditions like cancer. In oncology, CK1 antibodies help identify epithelial-derived tumors (carcinomas) through immunohistochemistry, aiding in tumor classification and metastasis detection. Dysregulation of CK1 expression has been linked to skin disorders, wound healing defects, and certain cancers. Commercially available CK1 antibodies are typically monoclonal or polyclonal, validated for applications including Western blotting, immunofluorescence, and flow cytometry. Their specificity varies, requiring careful validation using controls like knockout cells or tissues. Recent studies also explore CK1's role beyond structural support, such as its involvement in signaling pathways and stress responses, broadening the scope of CK1 antibody applications in molecular and cellular biology.