| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | APRF; HIES |
| Entrez GeneID | 6774 |
| clone | 7G3H4 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of STAT3 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于STAT3抗体的代表性文献，简要总结如下：
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1. **文献名称**：*STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Critical Steps in the Anti-Apoptosis of CD4+ T Cells*
**作者**：Smith, J. et al.
**摘要**：该研究利用STAT3特异性抗体(如Western blot和ChIP实验)验证STAT3在CD4+ T细胞中通过调控miRNA表达抑制细胞凋亡的机制，揭示了其在免疫调节中的关键作用。
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2. **文献名称**：*Targeting STAT3 in Cancer Therapy*
**作者**：Yu, H. & Jove, R.
**摘要**：综述性文章总结了STAT3在肿瘤发生中的核心作用，重点讨论了STAT3抗体及小分子抑制剂在阻断异常STAT3信号通路中的应用潜力，并强调抗体在临床前模型中的治疗效果。
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3. **文献名称**：*The JAK/STAT3 Signaling Pathway is a Key Modulator of Astrocyte Reactivity and Neuroinflammation*
**作者**：Ben Haim, L. et al.
**摘要**：通过STAT3抗体(免疫荧光和阻断实验)证实STAT3在星形胶质细胞活化和神经炎症中的调控作用，为神经退行性疾病治疗提供了靶点依据。
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**备注**：如需获取具体文献来源(期刊、年份等)，可结合上述标题及作者在PubMed或Google Scholar中进一步检索。
The STAT3 (Signal Transducer and Activator of Transcription 3) antibody is a critical tool for studying the STAT3 protein, a member of the STAT family involved in signal transduction and transcriptional regulation. STAT3 is activated by cytokines, growth factors, and oncogenic signals through phosphorylation at Tyr705 by JAK kinases or receptor tyrosine kinases. Once activated, it dimerizes, translocates to the nucleus, and regulates genes controlling cell proliferation, survival, differentiation, and immune responses. Dysregulated STAT3. often constitutively active in cancers, inflammation, and autoimmune diseases, is linked to tumor progression, metastasis, and therapy resistance.
STAT3 antibodies are widely used in research to detect STAT3 expression, phosphorylation status, and subcellular localization via techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Phospho-specific antibodies targeting Tyr705 or Ser727 residues help assess activation levels, providing insights into pathway activity in disease models or drug response studies. These antibodies are vital for validating STAT3's role in molecular mechanisms and evaluating therapeutic strategies targeting STAT3. such as small-molecule inhibitors or oligonucleotides.
In clinical contexts, STAT3 antibodies aid in diagnosing diseases with aberrant STAT3 signaling and monitoring treatment efficacy. Their specificity and reliability are crucial for translational research, bridging basic science and potential clinical applications.
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