| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| clone | 4A10 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified fusion protein with human IgG(Fc Specific) tag. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于human IgG (Fc specific)抗体的参考文献，信息基于公开研究内容整理：
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1. **标题**: *"Fc-specific antibodies enhance programmed death ligand 1 immune checkpoint inhibitory efficacy"*
**作者**: Smith et al.
**摘要**: 研究验证了Fc特异性抗体在增强PD-L1抑制剂治疗效果中的作用，证明其通过选择性结合抗体Fc区域，避免Fab段干扰，优化免疫检查点阻断疗法的特异性。
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2. **标题**: *"Development of a novel Fc-specific bispecific antibody platform for therapeutic applications"*
**作者**: Johnson & Lee
**摘要**: 提出一种新型Fc特异性双特异性抗体制备技术，利用Fc区域定向结合特性减少与非靶标分子的交叉反应，提升抗体药物在癌症治疗中的精准性。
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3. **标题**: *"Characterization of Fc-specific secondary antibodies for improved immunoassay sensitivity"*
**作者**: Müller et al.
**摘要**: 系统评估了多种商业化Fc特异性二抗在ELISA和流式细胞术中的性能，发现其能有效降低背景信号，提高检测信噪比，为实验设计提供优化依据。
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注：以上文献标题及内容为模拟示例，实际引用需通过学术数据库(如PubMed)核实具体信息。如需精确文献，建议结合关键词检索近年高被引论文。
Human IgG (Fc-specific) antibodies are specialized reagents designed to target the crystallizable fragment (Fc) region of immunoglobulin G (IgG), the most abundant antibody class in human serum. IgG molecules consist of two antigen-binding fragments (Fab) and a conserved Fc region. While Fab regions mediate antigen recognition, the Fc region facilitates immune effector functions, such as complement activation, antibody-dependent cellular cytotoxicity (ADCC), and binding to Fc gamma receptors (FcγRs) on immune cells.
Fc-specific antibodies are critical for applications requiring selective detection or modulation of IgG's Fc-mediated interactions. They avoid cross-reactivity with Fab regions or other antibody classes (e.g., IgM, IgA), ensuring specificity in assays like ELISA, Western blotting, and flow cytometry. These antibodies are widely used to study immune complex formation, Fc receptor signaling, therapeutic antibody mechanisms (e.g., monoclonal antibodies), and autoimmune diseases where Fc dysfunction is implicated.
Produced by immunizing animals with purified IgG Fc fragments or recombinant Fc proteins, Fc-specific antibodies undergo rigorous purification to remove Fab-directed cross-reactivity. Common host species include rabbits, goats, and mice. Their utility extends to diagnostics, biopharmaceutical quality control (e.g., assessing antibody glycosylation or Fc integrity), and therapeutic development, such as engineering Fc-optimized biologics or blocking pathological Fc-receptor interactions.
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