Mouse Monoclonal APBB1IP Antibody

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

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     Flow cytometric analysis of Hela cells using APBB1IP mouse mAb (green) and negative control (red).    

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     Immunohistochemical analysis of paraffin-embedded human lymph tissues using APBB1IP mouse mAb with DAB staining.    

The APBB1IP (Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein) antibody is a tool used to detect and study the APBB1IP protein, which plays roles in cell adhesion, migration, and immune regulation. APBB1IP, also known as RIAM (Rap1-GTP Interacting Adaptor Molecule), acts as an adaptor protein in intracellular signaling pathways, particularly linking Rap1 activation to integrin-mediated cell adhesion and cytoskeletal reorganization. It is crucial for processes like immune cell trafficking, platelet activation, and cancer cell metastasis.

The antibody is typically produced in hosts such as rabbits or mice, using immunogens derived from specific regions of the human APBB1IP protein. It enables researchers to investigate APBB1IP expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using this antibody have highlighted its relevance in diseases like cancer, where APBB1IP dysregulation may influence tumor invasiveness, and in immune disorders, given its role in T-cell and leukocyte activity. Validation of the antibody includes testing for specificity, sensitivity, and cross-reactivity, ensuring reliable detection in experimental models. Overall, the APBB1IP antibody serves as a key reagent for exploring cellular mechanisms and therapeutic targets in oncology and immunology.