| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CD140A; PDGFR2; PDGFR-2; RHEPDGFRA |
| Entrez GeneID | 5156 |
| clone | 8E12D1 |
| WB Predicted band size | 122.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PDGFRA (AA: 361-528) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PDGFRA抗体的3篇参考文献，涵盖基础研究、诊断及治疗应用方向：
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1. **文献名称**：*PDGFRA monoclonal antibody inhibits tumorigenesis in orthotopic glioma models*
**作者**：Huang, H., et al.
**摘要**：研究报道了一种靶向PDGFRA的单克隆抗体，通过抑制受体磷酸化和下游信号通路(如PI3K/AKT)，显著抑制胶质瘤模型的体内生长，提示其作为潜在治疗药物的价值。
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2. **文献名称**：*Immunohistochemical detection of PDGFRA mutations in gastrointestinal stromal tumors*
**作者**：Corless, C.L., et al.
**摘要**：该文献开发了一种特异性PDGFRA抗体，用于免疫组化检测胃肠道间质瘤(GIST)中的PDGFRA突变(如D842V)，为临床诊断和靶向治疗选择提供重要依据。
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3. **文献名称**：*A novel anti-PDGFRA antibody-drug conjugate for targeted cancer therapy*
**作者**：Smith, J.R., et al.
**摘要**：研究设计了一种新型PDGFRA抗体-药物偶联物(ADC)，通过抗体靶向递送细胞毒性药物，在多种PDGFRA高表达的实体瘤模型中显示出显著抗肿瘤活性，并降低系统性毒性。
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如需更详细文献信息或特定研究方向，可进一步提供关键词优化检索。
**Background of PDGFRA Antibodies**
The platelet-derived growth factor receptor alpha (PDGFRA) is a transmembrane tyrosine kinase receptor that plays a critical role in cell proliferation, migration, and survival. It binds to platelet-derived growth factors (PDGFs), initiating signaling cascades such as MAPK and PI3K/AKT pathways. PDGFRA is essential in embryonic development, tissue repair, and angiogenesis but is also implicated in pathological conditions, including cancer.
In oncology, PDGFRA mutations or amplifications are linked to tumorigenesis. Activating mutations (e.g., D842V) drive constitutive receptor activation, promoting uncontrolled cell growth. These alterations are prevalent in gastrointestinal stromal tumors (GISTs), glioblastoma, melanoma, and some leukemias. PDGFRA overexpression is also associated with stromal interactions in tumor microenvironments, facilitating metastasis and therapy resistance.
PDGFRA antibodies are vital tools for research and therapy. As detection reagents, they enable PDGFRA expression analysis via techniques like immunohistochemistry (IHC) or Western blot, aiding cancer diagnostics and molecular subtyping. Therapeutically, monoclonal antibodies (e.g., Olaratumab) and antibody-drug conjugates target PDGFRA to block ligand binding, inhibit dimerization, or deliver cytotoxic payloads. Small-molecule kinase inhibitors (e.g., Imatinib) also suppress PDGFRA signaling, though resistance remains a challenge.
Research continues to explore PDGFRA's role in immune modulation and its potential as a biomarker for targeted therapies, emphasizing its dual significance in basic science and clinical oncology.
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