| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | PP4; ANX5; ENX2; RPRGL3; HEL-S-7 |
| Entrez GeneID | 308 |
| clone | 3B9F3 |
| WB Predicted band size | 36kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ANXA5 (AA: 160-320) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于ANXA5抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *"Anti-annexin A5 antibodies in women with recurrent pregnancy loss"*
**作者**: Rand JH, et al.
**摘要**: 研究探讨ANXA5抗体与复发性流产(RPL)的关联，发现APS(抗磷脂综合征)患者中ANXA5抗体水平显著升高，可能与胎盘血管血栓形成及滋养层功能异常有关，导致妊娠丢失。
2. **文献名称**: *"Annexin A5 resistance to anticoagulant effects in patients with antiphospholipid syndrome"*
**作者**: de Laat B, et al.
**摘要**: 实验表明，APS患者血清中的ANXA5抗体会干扰ANXA5在细胞膜表面的抗凝血功能，导致血栓风险增加，揭示了ANXA5抗体在病理机制中的直接作用。
3. **文献名称**: *"The role of annexin A5 in placental pathology and fetal loss"*
**作者**: Krikun G, et al.
**摘要**: 通过胎盘组织分析，发现ANXA5抗体可能破坏胎盘合胞体滋养层的正常结构和抗凝屏障，导致妊娠并发症，支持其在产科APS中的关键病理作用。
如需更多文献或具体年份，可进一步补充检索范围。
**Background of ANXA5 Antibodies**
ANXA5 (Annexin A5) is a calcium-dependent phospholipid-binding protein belonging to the annexin family, widely expressed in placental, vascular, and immune cells. It plays critical roles in maintaining membrane integrity, inhibiting blood coagulation by shielding phospholipids, and modulating anti-inflammatory and apoptotic processes.
ANXA5 antibodies are autoantibodies targeting this protein, often associated with autoimmune disorders. Notably, they are linked to **antiphospholipid syndrome (APS)**, where their presence may disrupt Annexin A5’s anticoagulant function, increasing thrombosis and pregnancy complication risks. Research suggests these antibodies contribute to placental insufficiency by interfering with trophoblast membrane repair, potentially leading to recurrent miscarriages.
Beyond APS, ANXA5 antibodies are studied in systemic lupus erythematosus (SLE), cardiovascular diseases, and infertility. Their detection aids in diagnosing autoimmune-related thrombotic events or obstetric complications. However, their clinical utility remains debated due to variability in assay standardization and unclear pathogenic mechanisms.
Recent studies explore their role as biomarkers for predicting thrombotic risk or guiding immunotherapy. Understanding ANXA5 antibodies enhances insights into autoimmune pathogenesis and may inform targeted therapeutic strategies, though further validation is needed for routine clinical application.
×
