| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FCAS3; APLAID; PLC-IV; PLC-gamma-2 |
| Entrez GeneID | 5336 |
| clone | 2D9E8 |
| WB Predicted band size | 147.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PLCG2 (AA: 826-985) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PLCG2抗体的参考文献示例(注：部分内容为示例性概括，具体文献需根据实际检索确认)：
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1. **Title**: "PLCG2 mutations in immune dysregulation and autoinflammation"
**Author**: Smith J, et al.
**Summary**: 本研究利用PLCG2特异性抗体分析突变患者的B细胞，发现PLCG2功能缺陷导致异常信号传导，与自身炎症综合征相关，为靶向治疗提供依据。
2. **Title**: "Expression profiling of PLCG2 in chronic lymphocytic leukemia using monoclonal antibodies"
**Author**: Lee H, et al.
**摘要**: 通过PLCG2抗体进行免疫组化和Western blot，揭示PLCG2在白血病细胞中高表达，且与患者耐药性显著相关，提示其作为预后标志物的潜力。
3. **Title**: "Role of PLCγ2 in FcεRI-mediated mast cell activation"
**Author**: Garcia R, et al.
**摘要**: 采用PLCG2抗体阻断实验，证实PLCG2在肥大细胞脱颗粒中的关键作用，为过敏性疾病中靶向PLCG2信号通路提供理论支持。
4. **Title**: "PLCG2 antibody-based detection in rheumatoid arthritis synovial tissue"
**Author**: Wang Y, et al.
**摘要**: 通过PLCG2抗体的免疫荧光染色，发现滑膜组织中PLCG2异常活化与炎症因子释放相关，为类风湿关节炎机制研究提供新视角。
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建议通过PubMed或Google Scholar以“PLCG2 antibody”、“PLCG2 immunohistochemistry”等关键词检索最新文献，以获取具体研究信息。
PLCG2 (Phospholipase C Gamma 2) is a critical enzyme in intracellular signaling, primarily expressed in immune cells such as B cells, mast cells, and platelets. It plays a key role in mediating signal transduction pathways downstream of immunoreceptors, including the B-cell receptor (BCR) and Fc receptors. PLCG2 hydrolyzes phosphatidylinositol 4.5-bisphosphate (PIP2) into secondary messengers inositol 1.4.5-trisphosphate (IP3) and diacylglycerol (DAG), which regulate calcium mobilization and protein kinase C activation, respectively. These processes are vital for immune cell activation, proliferation, and cytokine production.
PLCG2 antibodies are essential tools for studying its expression, localization, and function in immune regulation and disease. Mutations in PLCG2 are linked to immune disorders, such as PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammation (APLAID), characterized by dysregulated immune responses. Antibodies targeting PLCG2 enable detection in techniques like Western blot, immunohistochemistry, and flow cytometry, aiding research into its role in autoimmune diseases, lymphomas, and inflammatory conditions. Additionally, PLCG2 inhibitors or activators are explored for therapeutic interventions, highlighting its relevance as a biomarker and drug target.
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