| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BDA2; BMP2A |
| Entrez GeneID | 650 |
| clone | 9E10D6 |
| WB Predicted band size | 44.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BMP2 (AA: 283-396) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4条关于BMP2抗体的虚构参考文献示例(仅供格式参考，实际文献需通过学术数据库检索)：
1. **文献名称**: "A monoclonal antibody targeting BMP2 enhances bone regeneration in murine models"
**作者**: Chen, X., et al.
**摘要**: 本研究开发了一种针对BMP2的单克隆抗体，通过激活下游SMAD信号通路促进成骨细胞分化，显著提高了小鼠颅骨缺损模型的骨再生效率，为骨修复治疗提供了新策略。
2. **文献名称**: "BMP2 antibody-based ELISA assay for early diagnosis of osteosarcoma"
**作者**: Smith, J.R., et al.
**摘要**: 文章建立了一种高灵敏度的BMP2抗体ELISA检测方法，用于定量分析骨肉瘤患者血清中BMP2的表达水平，结果显示其与肿瘤进展呈正相关，具有潜在临床诊断价值。
3. **文献名称**: "Neutralizing BMP2 antibody attenuates vascular calcification in atherosclerosis"
**作者**: Lee, H., et al.
**摘要**: 通过使用中和性BMP2抗体阻断BMP2与受体结合，显著减少了动脉粥样硬化模型中的血管钙化和炎症反应，提示其在心血管疾病治疗中的应用前景。
4. **文献名称**: "Cross-reactivity analysis of BMP2 antibodies with BMP family members"
**作者**: Garcia, M., et al.
**摘要**: 本研究评估了多种商业BMP2抗体的特异性，发现部分抗体与BMP4或BMP7存在交叉反应，强调了抗体验证在BMP信号通路研究中的重要性。
(注：以上为模拟内容，实际文献需通过PubMed/Google Scholar等平台以“BMP2 antibody”为关键词检索。)
The BMP2 (Bone Morphogenetic Protein 2) antibody is a tool used to detect and study BMP2. a key signaling protein in the TGF-β (Transforming Growth Factor-beta) superfamily. BMP2 plays critical roles in embryonic development, bone and cartilage formation, and tissue repair by regulating cell differentiation, proliferation, and apoptosis. Dysregulation of BMP2 is linked to skeletal disorders, cardiovascular diseases, and cancer, making it a focus of therapeutic research.
BMP2 antibodies, typically monoclonal or polyclonal, are generated using recombinant BMP2 protein or specific peptide sequences. They enable the detection of BMP2 in techniques like ELISA, Western blot, and immunohistochemistry (IHC), aiding in quantifying protein expression and localization in tissues or cell lines. Researchers use these antibodies to explore BMP2’s involvement in osteogenesis, stem cell differentiation, and pathological processes like tumor metastasis or fibrosis.
In therapeutic contexts, BMP2-neutralizing antibodies are investigated for conditions where excessive BMP2 signaling drives disease, such as certain cancers or heterotopic ossification. Conversely, recombinant BMP2 is used clinically to enhance bone regeneration, and antibodies help monitor its bioavailability. Challenges include ensuring antibody specificity due to structural similarities among BMP family members. Ongoing studies aim to refine antibody design for diagnostic accuracy and therapeutic efficacy.
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