Mouse Monoclonal BMP4 Antibody

The BMP4 (Bone Morphogenetic Protein 4) antibody is a key tool for studying the role of BMP4. a member of the TGF-β superfamily involved in embryonic development, tissue homeostasis, and disease. BMP4 regulates critical processes like cell differentiation, proliferation, apoptosis, and morphogenesis, particularly in neural tube formation, skeletal development, and organogenesis. Researchers use BMP4 antibodies to detect and quantify BMP4 expression in various biological samples via techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA. These antibodies are available as monoclonal or polyclonal forms, with monoclonal antibodies offering higher specificity and polyclonal antibodies providing broader epitope recognition. Applications span developmental biology, cancer research (as BMP4 dysregulation is linked to tumors), and regenerative medicine (e.g., stem cell differentiation studies). Validated BMP4 antibodies undergo rigorous testing for specificity, often using knockout controls, and batch-to-batch consistency to ensure reproducibility. Commercial suppliers (e.g., R&D Systems, Abcam) typically provide detailed protocols for optimal use in specific experimental conditions. Proper validation, including positive/negative controls and optimization of fixation or dilution factors, is essential to avoid cross-reactivity with related BMP family proteins.