| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2 |
| Entrez GeneID | 11141 |
| clone | 2H3C12 |
| WB Predicted band size | 80kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IL1RAPL1 (AA: 541-694) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与IL1RAPL1抗体相关的文献示例(文献名称及摘要内容为虚构模拟，仅作格式参考)：
1. **文献名称**: *IL1RAPL1 regulates excitatory synapse formation through PTPδ-mediated presynaptic differentiation*
**作者**: Yoshida T et al.
**摘要**: 研究利用IL1RAPL1特异性抗体在小鼠脑组织中验证其与突触蛋白PTPδ的相互作用，揭示IL1RAPL1通过调控突触前分化影响神经回路发育的机制。
2. **文献名称**: *Loss of IL1RAPL1 leads to cognitive deficits associated with altered dendritic spine morphology*
**作者**: Pavlowsky A et al.
**摘要**: 通过免疫组化(使用IL1RAPL1抗体)和基因敲除模型，证明IL1RAPL1缺失导致小鼠海马区树突棘形态异常，并引发学习记忆障碍。
3. **文献名称**: *IL1RAPL1 antibody-based proteomic analysis in X-linked intellectual disability*
**作者**: Valnegri P et al.
**摘要**: 研究开发高特异性IL1RAPL1单克隆抗体，用于患者脑脊液样本的蛋白质组学分析，发现其表达水平与X连锁智力障碍严重程度相关。
(注：以上文献为示例，实际引用需检索PubMed等数据库获取真实信息。)
The interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a protein encoded by the *IL1RAPL1* gene located on the X chromosome. It belongs to the IL-1 receptor/Toll-like receptor superfamily and plays a critical role in neurodevelopment, particularly in synapse formation and neuronal connectivity. IL1RAPL1 mutations are associated with X-linked intellectual disability (XLID), autism spectrum disorders (ASD), and neuropsychiatric conditions. The protein interacts with presynaptic partners like PTPδ to regulate excitatory synapse development and modulates intracellular signaling pathways involved in dendritic spine maturation.
Antibodies targeting IL1RAPL1 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They enable researchers to detect IL1RAPL1 in brain tissues, cell lines, or experimental models using techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies also aid in elucidating molecular mechanisms underlying synaptic defects in neurodevelopmental disorders. Commercially available IL1RAPL1 antibodies are typically validated for specificity, often targeting epitopes in the extracellular or cytoplasmic domains. Their applications extend to biomarker research and therapeutic exploration, as dysregulated IL1RAPL1 pathways are potential targets for treating cognitive impairments.
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