Mouse Monoclonal CFHR5 Antibody

The CFHR5 antibody targets Complement Factor H-Related Protein 5 (CFHR5), a member of the Factor H protein family involved in regulating the alternative complement pathway. CFHR5 shares structural homology with Factor H, a critical inhibitor of complement activation, but lacks certain regulatory domains, suggesting distinct functional roles. It is implicated in fine-tuning complement activity, potentially by competing with Factor H or modulating C5 convertase activity. Dysregulation of CFHR5 is linked to kidney diseases, notably CFHR5 nephropathy—a hereditary condition prevalent in Cypriot populations characterized by complement deposition in glomeruli. CFHR5 antibodies are vital tools for studying complement-mediated pathologies, including atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy, and age-related macular degeneration. Researchers use these antibodies in techniques like Western blot, immunohistochemistry, and ELISA to detect CFHR5 expression, assess its interaction with complement components, or evaluate tissue-specific complement activation. Mutations or autoantibodies against CFHR5 may disrupt complement homeostasis, contributing to thrombotic microangiopathies or autoimmune disorders. Recent studies also explore CFHR5's role in infections and its potential as a therapeutic target. Validated antibodies are essential for distinguishing CFHR5 from homologous proteins (e.g., Factor H, CFHR1-4) to avoid cross-reactivity, ensuring specificity in both research and clinical diagnostics.