| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Ly105 |
| Entrez GeneID | 24088 |
| clone | 8F11G10 |
| WB Predicted band size | 90kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of mouse Tlr2 (AA: 628-777) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于TLR2抗体的代表性文献概览(人工归纳，非实时数据库检索结果)：
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1. **文献名称**：*Recognition of Gram-positive bacterial lipoteichoic acid by Toll-like receptor 2*
**作者**：Alexopoulou, L., et al.
**摘要**：该研究通过TLR2抗体阻断实验，证明TLR2是识别革兰氏阳性菌脂磷壁酸(LTA)的关键受体，揭示了TLR2在细菌感染免疫中的核心作用。
2. **文献名称**：*Toll-like receptor 2-deficient mice are highly susceptible to Staphylococcus aureus infection*
**作者**：Takeda, K., et al.
**摘要**：利用TLR2基因缺陷小鼠及抗体抑制实验，证实TLR2缺失会导致宿主对金黄色葡萄球菌感染的清除能力显著下降，强调了TLR2在抗细菌免疫中的必要性。
3. **文献名称**：*Toll-like receptor signaling pathways*
**作者**：Kawasaki, T., & Kawai, T.
**摘要**：综述性文章，系统总结了TLR2及其抗体在信号通路研究中的应用，包括TLR2与其他TLRs的异源二聚化机制及其在炎症性疾病中的调控。
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**注**：如需实际引用，请通过PubMed或Google Scholar以上述标题/作者为关键词检索原文，并核对发表年份及期刊信息(如*Nature Immunology*, *Journal of Immunology*等)。
**Background of TLR2 Antibodies**
Toll-like receptor 2 (TLR2) is a key pattern recognition receptor in the innate immune system, responsible for detecting conserved microbial components such as bacterial lipoproteins, peptidoglycan, and lipoteichoic acid. It plays a critical role in initiating immune responses by activating signaling pathways (e.g., NF-κB, MAPK) that drive inflammation and host defense. TLR2 forms heterodimers with TLR1 or TLR6. enabling recognition of diverse pathogens.
TLR2 antibodies are essential tools for studying TLR2 expression, localization, and function in immune cells and tissues. They are widely used in techniques like flow cytometry, Western blotting, immunohistochemistry, and ELISA to quantify TLR2 levels or block its activity in experimental models. Researchers employ these antibodies to investigate TLR2's role in infectious diseases, autoimmune disorders (e.g., rheumatoid arthritis), atherosclerosis, and neurodegenerative conditions.
Monoclonal TLR2 antibodies offer high specificity, while polyclonal variants may detect broader epitopes. Challenges include ensuring cross-reactivity across species (human, mouse, rat) and distinguishing functional from non-functional receptor forms. Recent studies also explore therapeutic applications, such as modulating TLR2 signaling in sepsis or chronic inflammation. Overall, TLR2 antibodies remain pivotal in dissecting immune mechanisms and developing targeted therapies.
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