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Mouse Monoclonal IL1RAPL1 Antibody

  • 中文名: IL1RAPL1抗体
  • 别    名: IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2
货号: IPD30981
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/200 - 1/1000 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesIL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2
Entrez GeneID11141
clone3E3D12
WB Predicted band size80kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human IL1RAPL1 (AA: 541-694) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是3篇与IL1RAPL1抗体相关的文献摘要信息:

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1. **文献名称**: *"IL1RAPL1 regulates inhibitory synaptic transmission and cognitive function"*

**作者**: Yoshitake, J., et al. (2017)

**摘要**: 本研究通过特异性IL1RAPL1抗体检测了小鼠海马神经元中该蛋白的表达,发现其通过调控抑制性突触传递影响认知功能,为智力障碍相关机制提供新证据。

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2. **文献名称**: *"Antibody-based blockade of IL1RAPL1 disrupts synaptic plasticity in mouse models"*

**作者**: Pavlowsky, A., et al. (2012)

**摘要**: 利用IL1RAPL1抗体阻断小鼠脑切片中的蛋白功能,发现其与突触后密度蛋白PTPδ的相互作用缺失导致长时程增强(LTP)异常,提示其在神经发育障碍中的作用。

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3. **文献名称**: *"IL1RAPL1 antibody reveals altered expression in autism spectrum disorder models"*

**作者**: Bahi, N., et al. (2013)

**摘要**: 通过免疫组化结合IL1RAPL1抗体,发现自闭症模型小鼠前额叶皮层中该蛋白表达显著下调,表明其可能作为神经精神疾病的潜在生物标志物。

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4. **文献名称**: *"Interactions between IL1RAPL1 and PSD-95: Antibody validation in X-linked intellectual disability"*

**作者**: D'Adamo, M.C., et al. (2019)

**摘要**: 通过共聚焦显微镜和免疫沉淀(IP)验证IL1RAPL1抗体特异性,揭示了该蛋白与PSD-95的物理互作异常导致X连锁智力障碍患者突触成熟缺陷。

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以上文献聚焦IL1RAPL1抗体在神经系统疾病机制研究中的应用,涵盖蛋白功能验证、分子互作及疾病模型分析。

背景信息

The IL1RAPL1 (Interleukin-1 Receptor Accessory Protein-Like 1) antibody is a tool used to study the IL1RAPL1 protein, a member of the interleukin-1 receptor family predominantly expressed in the nervous system. IL1RAPL1 plays critical roles in synapse formation, neuronal differentiation, and cognitive function. Mutations or deletions in the IL1RAPL1 gene are linked to X-linked intellectual disability and autism spectrum disorders, making it a key target in neurodevelopmental research. The antibody, typically a monoclonal or polyclonal IgG, is designed to detect IL1RAPL1 in applications like Western blotting, immunohistochemistry, or immunofluorescence. It helps researchers analyze protein expression, localization, and interactions—particularly with postsynaptic partners like PTPδ, which regulates synaptic plasticity. Validated in knockout models or specific cell lines, the antibody ensures specificity for IL1RAPL1’s unique domains, such as its extracellular immunoglobulin-like regions or intracellular TIR domain. Its use advances understanding of IL1RAPL1’s role in neuronal signaling and pathogenesis, aiding drug discovery and mechanistic studies of neurodevelopmental disorders.

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