Mouse Monoclonal MOB1A Antibody

MOB1A (Mps One Binder Kinase Activator 1A) is a key component of the Hippo signaling pathway, a conserved regulator of organ size, cell proliferation, apoptosis, and tissue homeostasis. It shares homology with MOB1B and functions as a scaffold protein that interacts with large tumor suppressor kinases LATS1/2 to facilitate their activation. MOB1A forms a complex with MST1/2 (Hippo homologs) and LATS1/2. promoting LATS-mediated phosphorylation of transcriptional coactivators YAP/TAZ, which leads to their cytoplasmic retention or degradation. This pathway is critical in restraining oncogenic growth, and dysregulation of MOB1A has been linked to cancer, developmental disorders, and tissue overgrowth. Structurally, MOB1A contains an N-terminal kinase-binding domain and a conserved Mob1/Phocein domain mediating phosphorylation-dependent interactions. Antibodies targeting MOB1A are widely used in research to detect its expression, subcellular localization, and interactions in Hippo pathway studies. They aid in elucidating mechanisms underlying cell cycle control, contact inhibition, and tumor suppression. Commercial MOB1A antibodies are typically validated for applications like Western blotting, immunoprecipitation, and immunofluorescence. Dysfunctional MOB1A or Hippo signaling is implicated in cancers such as hepatocellular carcinoma and glioblastoma, making these antibodies valuable tools for both basic research and potential diagnostic/prognostic biomarker development.