| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IGLC |
| Entrez GeneID | 3538 |
| clone | 5E12B9 |
| WB Predicted band size | 11.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IGLC2 (AA: 1-106) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IGLC2抗体的虚构示例参考文献(实际文献需通过学术数据库检索)：
1. **《IGLC2作为多发性骨髓瘤诊断标志物的研究》**
- 作者：Smith A, et al.
- 摘要：探讨IGLC2抗体在检测多发性骨髓瘤患者血清异常轻链表达中的特异性，验证其作为潜在生物标志物的临床价值。
2. **《免疫球蛋白轻链基因重组中IGLC2的功能分析》**
- 作者：Li Y, et al.
- 摘要：通过IGLC2抗体标记技术，揭示IGLC2在B细胞发育过程中轻链可变区重组的作用及其调控机制。
3. **《基于单细胞测序的IGLC2抗体筛选与优化》**
- 作者：Wang X, et al.
- 摘要：报道一种新型IGLC2单克隆抗体的开发流程，评估其在流式细胞术和免疫组化中的应用效能。
4. **《自身免疫疾病中IGLC2异常表达的免疫学研究》**
- 作者：Garcia R, et al.
- 摘要：利用IGLC2抗体检测系统性红斑狼疮患者外周血B细胞，发现IGLC2过度表达与疾病活动性的相关性。
**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“IGLC2 antibody”或“immunoglobulin lambda constant 2”获取。
The IGLC2 antibody targets the immunoglobulin lambda constant 2 (IGLC2) protein, a component of the lambda light chain in immunoglobulins (antibodies). Immunoglobulins consist of two heavy chains and two light chains (kappa or lambda), with lambda chains encoded by gene clusters including IGLC2. This protein contributes to the constant region of antibodies, influencing their structural stability and effector functions, such as complement activation and receptor binding.
IGLC2 antibodies are primarily used in research to study B-cell development, antibody diversity, and pathologies involving lambda light chains, such as B-cell malignancies (e.g., multiple myeloma) or autoimmune disorders. They help detect lambda chain expression in tissues or serum, aiding in diagnostics and subtyping of monoclonal gammopathies.
Commercial IGLC2 antibodies are typically monoclonal or polyclonal, validated for techniques like immunohistochemistry, flow cytometry, or Western blot. Challenges include cross-reactivity with homologous lambda chain isoforms (e.g., IGLC1. IGLC3), necessitating careful validation. Recent studies also explore IGLC2's role in immune microenvironment regulation, highlighting its potential as a therapeutic target or biomarker. Overall, IGLC2 antibodies are vital tools for understanding humoral immunity and related diseases.
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