Mouse Monoclonal TFAP2B Antibody

The TFAP2B antibody is a crucial tool in studying the transcription factor AP-2 beta (TFAP2B), a member of the AP-2 family of DNA-binding proteins involved in regulating gene expression during embryonic development and cell differentiation. TFAP2B plays a key role in neural crest cell development, craniofacial morphogenesis, and the formation of tissues such as kidneys, skin, and limbs. It is also implicated in metabolic regulation and adipose tissue function. Mutations in the TFAP2B gene are linked to Char syndrome, a rare genetic disorder characterized by craniofacial, cardiac, and limb abnormalities, as well as familial dilated cardiomyopathy. Researchers use TFAP2B antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect TFAP2B protein expression, localization, and interaction partners in both normal and diseased tissues. These antibodies help elucidate TFAP2B's role in developmental pathways, tumorigenesis (e.g., neuroblastoma, breast cancer), and metabolic diseases. Commercial TFAP2B antibodies are typically raised in rabbits or mice against specific epitopes of the human TFAP2B protein, with validation in knockout controls to ensure specificity. Their applications span basic research, diagnostic pathology, and therapeutic target validation.