| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HOXA3 |
| Uniprot No | O43365 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-443aa |
| 氨基酸序列 | MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPHAHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLGSGHHHGPGPGEPHPTYTDLTGHHPSQGRIQEAPKLTHL |
| 预测分子量 | 47.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于HOXA3重组蛋白的3篇虚构参考文献示例(基于领域内常见研究方向概括，非真实文献)：
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1. **"HOXA3 Recombinant Protein Enhances Angiogenesis in Ischemic Injury Models"**
*Authors: Smith J, et al. (Journal of Molecular Medicine, 2020)*
**摘要**: 本研究证明重组HOXA3蛋白通过激活整合素信号通路促进内皮细胞迁移和血管生成，在缺血性小鼠模型中显著改善组织血流恢复，提示其潜在治疗价值。
2. **"HOXA3 Regulates Epithelial-Mesenchymal Transition via TGF-β Pathway"**
*Authors: Chen L, et al. (Cell Regeneration, 2018)*
**摘要**: 报道重组HOXA3蛋白通过调控TGF-β/Smad信号通路抑制上皮-间质转化(EMT)，减缓肿瘤细胞侵袭，为癌症靶向治疗提供新思路。
3. **"HOXA3 Recombinant Protein Modulates Inflammatory Responses in Macrophages"**
*Authors: Garcia R, et al. (Journal of Immunology, 2021)*
**摘要**: 研究发现HOXA3重组蛋白通过抑制NF-κB活性减少促炎因子释放，在脓毒症模型中降低全身炎症反应，提出其在炎症性疾病中的治疗潜力。
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注：以上文献为示例性质，实际研究需查阅真实数据库(如PubMed)。HOXA3的实际功能可能涉及胚胎发育、细胞分化及疾病调控等方向。
**Background of HOXA3 Recombinant Protein**
The HOXA3 gene belongs to the homeobox (HOX) family, a group of evolutionarily conserved transcription factors critical for embryonic development, particularly in establishing body segmentation and axial patterning. HOX proteins, including HOXA3. regulate cell differentiation, tissue morphogenesis, and organogenesis by binding to DNA via their conserved homeodomain, thereby controlling the expression of downstream target genes. HOXA3 is specifically implicated in the development of the posterior hindbrain, cervical vertebrae, and anterior limbs, as well as vascular and neural systems.
Recombinant HOXA3 protein is engineered using biotechnological methods (e.g., bacterial or mammalian expression systems) to produce a purified, functional form of the native protein for research and therapeutic applications. This protein typically includes the full-length or functional domains (e.g., the homeodomain) required for DNA binding and transcriptional regulation. Researchers utilize recombinant HOXA3 to study its role in developmental biology, cellular differentiation, and disease mechanisms, such as cancer metastasis or tissue regeneration.
Recent studies highlight its potential in regenerative medicine, particularly in promoting angiogenesis, wound healing, and tissue repair. For instance, HOXA3 has been shown to enhance endothelial cell migration and vascular remodeling in ischemic injury models. However, challenges remain in optimizing its stability, solubility, and delivery in vivo. Structural and functional analyses of recombinant HOXA3 continue to advance drug discovery efforts, aiming to harness its therapeutic potential while mitigating off-target effects. Overall, HOXA3 recombinant protein serves as a vital tool for deciphering developmental pathways and exploring novel treatments for congenital disorders, injuries, and degenerative diseases.
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