| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | EAA5; GLR7; GLUR7; GluK3; GluR7a |
| Entrez GeneID | 2899 |
| clone | 2B4H1 |
| WB Predicted band size | 104kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GRIK3 (AA: extra 32-173) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于GRIK3抗体的3篇参考文献示例(注：文献为虚构示例，仅作格式参考)：
---
1. **文献名称**：*"Characterization of GRIK3 Antibody Specificity in Postmortem Human Brain Tissue"*
**作者**：Smith J, et al.
**摘要**：本研究验证了两种商业GRIK3抗体的特异性，通过Western blot和免疫组化分析发现其在人脑前额叶皮层和海马中特异性标记GRIK3蛋白，为神经精神疾病研究提供可靠工具。
2. **文献名称**：*"Altered GRIK3 Expression in Schizophrenia: An Immunohistochemical Study"*
**作者**：Chen L, et al.
**摘要**：利用GRIK3抗体对精神分裂症患者脑组织进行免疫染色，发现患者丘脑区域GRIK3蛋白表达显著降低，提示其可能与疾病病理机制相关。
3. **文献名称**：*"GRIK3 Antibody-Based Profiling Reveals Synaptic Localization in Murine Cortical Neurons"*
**作者**：Rodriguez M, et al.
**摘要**：通过共聚焦显微镜结合GRIK3抗体，证实GRIK3蛋白在小鼠皮层神经元突触后膜富集，支持其在谷氨酸能信号传递中的功能。
---
以上示例展示了GRIK3抗体在特异性验证、疾病研究和亚细胞定位中的应用场景。实际文献需通过学术数据库(如PubMed)检索确认。
The glutamate ionotropic receptor kainate type subunit 3 (GRIK3), also known as GluK3. is a protein encoded by the GRIK3 gene in humans. It forms part of the kainate family of glutamate-gated ion channels, which mediate excitatory neurotransmission in the central nervous system. These receptors are involved in synaptic plasticity, neuronal development, and the modulation of neurotransmitter release. GRIK3 specifically assembles with other subunits (GluK1-GluK5) to form functional tetrameric receptors, influencing synaptic strength and circuit connectivity.
Antibodies targeting GRIK3 are essential tools for studying its expression, localization, and functional roles in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to map GRIK3 distribution in brain regions such as the hippocampus, cortex, and amygdala. Research has linked GRIK3 dysregulation to neuropsychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorders, making these antibodies critical for investigating disease mechanisms. Additionally, GRIK3 antibodies aid in exploring potential therapeutic strategies, such as receptor modulation for treating cognitive deficits or epilepsy. Their specificity is validated through knockout controls or peptide-blocking assays to ensure accurate detection. Understanding GRIK3's role through antibody-based studies continues to advance insights into glutamate signaling complexity and its implications for brain health.
×
