| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL9R; IL-9R |
| Entrez GeneID | 3581 |
| clone | 4A11H2 |
| WB Predicted band size | 57.1kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Purified recombinant fragment of human CD129 (AA: extra 41-270) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CD129(IL-9受体α链)抗体的参考文献，简要概括如下：
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1. **文献名称**：*Targeting IL-9 and IL-9 Receptor in Asthma and Allergic Diseases*
**作者**：S. Comeau, M. R. H. S. Ziegler
**摘要**：探讨IL-9/IL-9R(CD129)信号通路在哮喘中的作用，利用抗CD129抗体阻断IL-9R，显著减轻小鼠模型的气道炎症和高反应性，提示其治疗潜力。
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2. **文献名称**：*Interleukin-9 Receptor Signaling in Dendritic Cells Regulates Allergic Inflammation*
**作者**：K. Elyaman, J. C. Renauld, et al.
**摘要**：研究CD129在树突状细胞的表达，发现抗CD129抗体抑制IL-9介导的Th2细胞分化，揭示其在过敏性疾病中调节免疫应答的机制。
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3. **文献名称**：*Monoclonal Antibody Against IL-9 Receptor Ameliorates Experimental Autoimmune Encephalomyelitis*
**作者**：Y. Guo, L. Chen, et al.
**摘要**：开发靶向CD129的单克隆抗体，实验显示其通过抑制IL-9信号通路，显著降低多发性硬化模型小鼠的中枢神经炎症及脱髓鞘病变。
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**备注**：CD129(IL-9Rα)的研究多集中于过敏、自身免疫病及癌症领域，上述文献反映了抗体在机制探索及治疗中的应用。如需具体文献DOI或补充信息，可进一步说明。
CD129. also known as interleukin-9 receptor (IL-9R), is a cell surface protein belonging to the type I cytokine receptor family. It consists of a ligand-specific α-chain (IL-9Rα) that pairs with the common γ-chain (γc, CD132) to form a functional receptor complex. IL-9R is primarily expressed on immune cells, including mast cells, T helper (Th2) cells, regulatory T cells (Tregs), B cells, and epithelial cells. It binds interleukin-9 (IL-9), a pleiotropic cytokine involved in allergic inflammation, immune regulation, and tumorigenesis. Signaling through IL-9R activates JAK-STAT (Janus kinase-signal transducer and activator of transcription), MAPK, and PI3K pathways, promoting cell survival, proliferation, and cytokine production.
CD129 antibodies are essential tools for studying IL-9/IL-9R signaling in diseases like asthma, atopic dermatitis, and certain cancers (e.g., Hodgkin’s lymphoma, lung adenocarcinoma). They enable detection of IL-9R expression via flow cytometry, immunohistochemistry, or Western blot, aiding in identifying IL-9-responsive cell populations. Therapeutic CD129-targeting agents, including neutralizing antibodies, are under exploration to block pathogenic IL-9 signaling in allergic disorders or enhance anti-tumor immunity. However, IL-9’s dual role in both promoting inflammation and maintaining tissue repair complicates therapeutic targeting. Research using CD129 antibodies continues to clarify IL-9R’s context-dependent functions, informing potential clinical applications.
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