| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | NECTIN3; PPR3; PRR3; PVRL3; PVRR3; CDW113; NECTIN-3 |
| Entrez GeneID | 25945 |
| clone | 6D5B2 |
| WB Predicted band size | 61kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD113 (AA: extra 282-404) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD113抗体的3篇参考文献示例(内容基于常见研究领域，建议通过学术数据库核实具体文献)：
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1. **文献名称**：*CD113 Expression Correlates with Tumor Progression in Colorectal Cancer*
**作者**：Smith A, et al. (2020)
**摘要**：该研究通过CD113抗体检测结直肠癌组织中CD113(Tspan7)的表达，发现其高表达与患者预后不良显著相关，提示CD113可能作为潜在的肿瘤标志物或治疗靶点。
2. **文献名称**：*CD113 Modulates Dendritic Cell Migration via Integrin Signaling*
**作者**：Johnson R, et al. (2018)
**摘要**：研究利用CD113抗体阻断实验，发现CD113通过调控整合素信号通路影响树突状细胞的迁移能力，揭示了其在免疫应答中的关键作用。
3. **文献名称**：*CD113 Serves as a Receptor for Oncolytic Virus Entry*
**作者**：Lee H, et al. (2019)
**摘要**：该研究证实CD113抗体可特异性抑制某种溶瘤病毒对宿主细胞的入侵，表明CD113是病毒感染的受体分子，为抗病毒治疗提供新思路。
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**注意**：上述文献为示例性质，实际研究中请通过PubMed、Google Scholar等平台以关键词“CD113 antibody”、“Tspan7 function”或结合具体研究领域(如肿瘤、免疫)检索最新文献。
**Background of CD113 Antibody**
CD113. also known as poliovirus receptor-related protein 1 (PVRR1) or nectin-1. is a transmembrane glycoprotein belonging to the nectin family of cell adhesion molecules. It plays a critical role in cell-cell adhesion, immune regulation, and viral entry, particularly as a receptor for herpes simplex virus (HSV) and pseudorabies virus. CD113 is widely expressed in epithelial cells, neurons, and immune cells, and it interacts with intracellular afadin to mediate signaling and cytoskeletal reorganization.
CD113 antibodies are immunological tools designed to detect or modulate CD113 protein expression. They are widely utilized in research to investigate viral pathogenesis, cell adhesion dynamics, and immune responses. For example, anti-CD113 antibodies can block HSV entry into host cells, aiding in studies of viral infection mechanisms. Additionally, these antibodies are employed in techniques like flow cytometry, immunohistochemistry, and Western blotting to assess CD113 expression patterns in healthy and diseased tissues, including cancers and inflammatory conditions.
Emerging studies also explore CD113's role in immune evasion and its potential as a therapeutic target. However, nomenclature inconsistencies (e.g., overlap with CD155 or other nectin family members) require careful validation of antibody specificity. Overall, CD113 antibodies remain vital for elucidating the biological and pathological significance of this multifaceted protein.
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