| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CLEC10A; HML; MGL; HML2; CLECSF13; CLECSF14 |
| Entrez GeneID | 10462 |
| clone | 2C5C6F10 |
| WB Predicted band size | 35.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD301 (AA: extra 158-316) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD301抗体的模拟参考文献示例，基于典型研究方向概括：
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1. **文献名称**：*Targeting CD301+ macrophages as a novel immunotherapy against metastatic cancer*
**作者**：Li X, et al.
**摘要**：该研究探讨了CD301抗体靶向肿瘤相关巨噬细胞(TAMs)的潜力。实验表明，阻断CD301+ TAMs可逆转免疫抑制微环境，增强T细胞抗肿瘤活性，抑制小鼠转移性肿瘤生长。
2. **文献名称**：*CLEC10A (CD301) is a functional marker of human monocyte-derived dendritic cells*
**作者**：van Vliet SJ, et al.
**摘要**：研究验证了CD301抗体在人单核细胞来源树突状细胞(MoDCs)中的应用，证明CD301作为功能性标记物参与糖基化抗原摄取，并调控TLR诱导的免疫应答极化。
3. **文献名称**：*CD301b+ dendritic cells in tolerance and allergy*
**作者**：Sancho D, et al.
**摘要**：通过CD301抗体分选小鼠树突状细胞亚群，发现CD301b+ DCs在诱导外周免疫耐受中的作用，为自身免疫疾病治疗提供新靶点。
4. **文献名称**：*Antibody-directed targeting of CD301+ cells enhances vaccine efficacy*
**作者**：Singh SK, et al.
**摘要**：开发了一种CD301抗体-抗原偶联疫苗，证明其可高效激活抗原特异性T细胞，改善感染模型中的病原体清除能力。
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注：以上为模拟文献，实际引用需查询数据库(如PubMed)获取真实论文。
CD301 antibody targets the CD301 molecule, also known as CLEC10A (C-type lectin domain-containing 10A) or human macrophage galactose-type C-type lectin (MGL). CD301 is a transmembrane protein belonging to the C-type lectin receptor family, characterized by carbohydrate recognition domains that bind glycans terminating in galactose or N-acetylgalactosamine (Gal/GalNAc). It is primarily expressed on antigen-presenting cells (APCs), including dendritic cells (DCs) and macrophages, where it plays a role in immune modulation, pathogen recognition, and cellular interactions.
CD301 is implicated in promoting Th2-type immune responses, tolerance induction, and anti-inflammatory signaling. It binds to glycan structures on pathogens, tumor-associated antigens, and apoptotic cells, facilitating their uptake and processing. CD301 antibodies are widely used in research to identify specific subsets of APCs, particularly M2-polarized macrophages or regulatory DCs, in contexts like cancer, allergy, and autoimmune diseases. Studies also explore its therapeutic potential, as targeting CD301 may influence immune tolerance in cancer immunotherapy or inflammatory disorders.
In mice, homologous receptors (MGL1/MGL2) share functional similarities, aiding translational research. CD301 antibodies thus serve as critical tools for dissecting immune cell heterogeneity and glycan-mediated immune regulation.
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