| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL18R1; IL18RA; IL1RRP; CDw218a; IL-1Rrp |
| Entrez GeneID | 8809 |
| clone | 2B7E6 |
| WB Predicted band size | 62.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD218A (AA: extra 22-185) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD218A(IL-18Rα)抗体的模拟参考文献示例(仅供学术参考，具体文献需通过数据库核实)：
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1. **《IL-18 receptor α-dependent natural killer cell activation mediates colitis pathogenesis》**
- **作者**: Smith J, et al.
- **摘要**: 研究揭示了CD218A在NK细胞介导的肠道炎症中的作用，通过抗体阻断实验证明其参与IL-18信号通路调控，为炎症性肠病治疗提供新靶点。
2. **《Structural characterization of the IL-18/IL-18Rα complex using monoclonal antibodies》**
- **作者**: Lee S, et al.
- **摘要**: 通过抗CD218A单克隆抗体解析IL-18与其受体的结合表位，阐明受体激活的分子机制，为开发靶向抑制剂奠定基础。
3. **《CD218A as a biomarker for Th1-mediated autoimmune diseases》**
- **作者**: Garcia R, et al.
- **摘要**: 分析类风湿性关节炎患者中CD218A表达水平，发现其与疾病活动度正相关，提示该抗体可作为Th1型免疫反应的临床标志物。
4. **《Therapeutic targeting of IL-18Rα in a murine model of sepsis》**
- **作者**: Wang H, et al.
- **摘要**: 使用抗CD218A抗体抑制IL-18信号通路，显著降低脓毒症模型小鼠的全身炎症反应和死亡率，证明其治疗潜力。
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建议通过PubMed或Web of Science以“CD218A antibody”或“IL-18Rα antibody”为关键词检索最新文献。
CD218a antibody targets the CD218a antigen, also known as interleukin-18 receptor alpha (IL-18Rα), a key component of the IL-18 receptor complex. IL-18 is a pro-inflammatory cytokine involved in innate and adaptive immunity, particularly in promoting Th1 cell responses and NK cell activity. The IL-18Rα subunit binds IL-18 with low affinity, requiring association with the β-chain (CD218b/IL-18Rβ) to form a high-affinity signaling receptor. CD218a is expressed on immune cells, including T cells, NK cells, macrophages, and dendritic cells, and its activation triggers downstream pathways like NF-κB and MAPK, driving inflammatory responses.
CD218a antibodies are essential tools in studying IL-18 signaling mechanisms, receptor expression patterns, and dysregulation in diseases such as autoimmune disorders, chronic inflammation, and cancer. They are used in techniques like flow cytometry, Western blotting, and immunohistochemistry to detect receptor presence or block IL-18 interactions. Research using these antibodies has highlighted IL-18Rα's role in pathologies like rheumatoid arthritis, inflammatory bowel disease, and sepsis, making it a potential therapeutic target. Monoclonal anti-CD218a antibodies are also explored for therapeutic applications to modulate excessive inflammation. Understanding CD218a's function through antibody-based studies continues to advance insights into immune regulation and therapeutic intervention strategies.
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