| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BWS; WBS; p57; BWCR; KIP2; p57Kip2 |
| Entrez GeneID | 1028 |
| clone | 1F4A9 |
| WB Predicted band size | 32.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CDKN1C expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CDKN1C抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"CDKN1C/p57KIP2 in human cancer: tumor suppressor or oncogene?"*
**作者**: Lee MH, Yang HY
**摘要**: 本文探讨CDKN1C在多种癌症中的双重作用，利用特异性抗体分析其在肿瘤组织中的表达模式，发现其在某些癌症中因启动子高甲基化表达下调，而在另一些肿瘤中异常高表达可能与基因组印记失调相关。
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2. **文献名称**: *"Immunohistochemical detection of p57KIP2 in hydatidiform moles"*
**作者**: Fukunaga M, Ushigome S
**摘要**: 研究使用CDKN1C/p57KIP2抗体通过免疫组化区分完全性葡萄胎与部分性葡萄胎，结果显示母体来源的p57KIP2表达缺失可作为完全性葡萄胎的诊断标志，验证了该抗体的临床病理应用价值。
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3. **文献名称**: *"Epigenetic regulation of CDKN1C in Beckwith-Wiedemann syndrome"*
**作者**: Weksberg R, Shuman C, Smith AC
**摘要**: 通过Western blot和免疫荧光技术，研究证实CDKN1C抗体可检测患者细胞中基因的印记缺失或低表达，揭示了其在Beckwith-Wiedemann综合征中的表观遗传调控机制及生长异常表型关联。
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如需更多文献或具体应用方向(如实验技术细节)，可进一步补充说明。
CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C), also known as p57KIP2. is a protein encoded by the *CDKN1C* gene located on chromosome 11p15.5. It belongs to the Cip/Kip family of cyclin-dependent kinase inhibitors (CKIs) and plays a critical role in regulating cell cycle progression by inhibiting G1-phase cyclin-CDK complexes, thereby preventing cell cycle transition from G1 to S phase. CDKN1C is particularly important during embryonic development, where it modulates cellular proliferation, differentiation, and apoptosis. Dysregulation of CDKN1C expression, due to genetic mutations, epigenetic alterations (e.g., loss of imprinting), or post-translational modifications, is linked to developmental disorders like Beckwith-Wiedemann syndrome (BWS) and cancers, including certain pediatric tumors and adult carcinomas.
CDKN1C antibodies are immunological tools designed to detect and quantify the p57KIP2 protein in various research and diagnostic applications. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CDKN1C expression patterns in tissues, assess its role in cell cycle regulation, and investigate its association with diseases. Monoclonal and polyclonal CDKN1C antibodies are available, often validated for specificity and sensitivity. Their utility extends to cancer research, where altered CDKN1C levels may serve as biomarkers, and in developmental biology studies exploring imprinting disorders. Reliable CDKN1C antibodies are essential for advancing understanding of its tumor-suppressive functions and therapeutic potential.
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