| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HSA; PRO0883; PRO0903; PRO1341 |
| Entrez GeneID | 213 |
| clone | 3F6E5 |
| WB Predicted band size | 69.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ALB (AA: 410-609) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ALB(白蛋白)抗体的3篇文献示例，包含文献名称、作者及摘要概括：
1. **《Monoclonal Antibodies Against Human Serum Albumin: Production and Characterization》**
- **作者**: Smith J, et al.
- **摘要**: 研究报道了针对人血清白蛋白(HSA)的单克隆抗体的开发与特性分析，通过杂交瘤技术制备高特异性抗体，并验证其在免疫检测中的灵敏度和交叉反应性，为临床诊断工具开发提供基础。
2. **《Albumin-Specific Autoantibodies in Chronic Liver Disease》**
- **作者**: Lee S, et al.
- **摘要**: 探讨慢性肝病患者血清中白蛋白自身抗体的存在及其临床意义，发现部分肝硬化患者体内存在抗ALB IgG抗体，可能与疾病进展和代谢异常相关。
3. **《Urinary Albumin Detection Using Nanobody-Based Immunoassays for Early Diabetic Nephropathy Diagnosis》**
- **作者**: Zhang Y, et al.
- **摘要**: 研究基于纳米抗体(单域抗体)设计新型免疫检测方法，用于高灵敏度检测尿液中微量白蛋白，提升糖尿病肾病的早期诊断效率，并验证其优于传统ELISA试剂的性能。
4. **《Albumin-Binding Antibodies in Drug Delivery: Engineering and Applications》**
- **作者**: Wang H, et al.
- **摘要**: 综述白蛋白结合抗体的工程化策略及其在靶向药物递送系统中的应用，重点讨论抗体片段延长药物半衰期、增强肿瘤靶向性的机制及临床前研究进展。
(注：以上文献为示例，实际引用需以真实发表的论文为准。)
Albumin (ALB) antibodies are immunological tools targeting albumin, the most abundant plasma protein in vertebrates. Synthesized primarily in the liver, albumin plays critical roles in maintaining osmotic pressure, transporting hormones, fatty acids, and drugs, and regulating antioxidant processes. ALB antibodies, either polyclonal or monoclonal, are generated by immunizing host animals (e.g., rabbits, mice) with purified albumin proteins. These antibodies specifically recognize epitopes on albumin across species, enabling applications in research, diagnostics, and therapeutics.
In research, ALB antibodies are widely used in immunoassays (ELISA, Western blot, immunohistochemistry) to quantify albumin levels, study its expression in tissues, or investigate its interaction with ligands. Clinically, they aid in diagnosing conditions like liver dysfunction, nephrotic syndrome, or malnutrition, where albumin levels serve as biomarkers. Additionally, ALB antibodies are employed in pharmacokinetic studies to monitor drug-albumin binding or to develop albumin-based drug delivery systems. Cross-reactivity with albumin from different species requires careful validation to avoid interference in experimental models. High specificity and affinity are critical for ensuring accuracy, driving ongoing optimization in antibody production and purification techniques.
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